抑癌基因PTEN及P16蛋白在疣状胃炎及胃癌组织中的表达及意义  

Expression of PTEN and P16 proteins in varioliform gastritis and gastric cancer

作　　者：丁世华[1] 刘俊[1] 舒晴[1] 王建平[1] 邓联民[1] 刘新民[1] 

机构地区：[1]深圳市第二人民医院消化科,广东省深圳市518035

出　　处：《世界华人消化杂志》2010年第19期2047-2049,共3页World Chinese Journal of Digestology

基　　金：深圳市科技局基金资助项目;No.200902042~~

摘　　要：目的:探讨疣状胃炎与胃癌之间的关系.方法:采用免疫组织化学法检测PTEN及P16蛋白在慢性浅表性胃炎、疣状胃炎及胃癌组织中的表达.结果:疣状胃炎组PTEN蛋白阳性率显著低于慢性浅表性胃炎组(44.4%vs92%,χ2=14.47,P<0.01),而与胃癌组(25.8%)比较无显著差异(χ2=2.51,P>0.05).疣状胃炎组P16蛋白阳性率显著低于慢性浅表性胃炎组(50%vs96%,χ2=14.56,P<0.01),但明显高于胃癌组(19.4%)(χ2=6.80,P<0.01).结论:抑癌基因PTEN及P16可能参与了疣状胃炎癌变过程.AIM：To explore the relationship between varioliform gastritis and gastric cancer.METHODS：The expression of PTEN and P16 proteins in chronic superficial gastritis,varioliform gastritis and gastric cancer was detected by immunohistochemistry.RESULTS：The positive rate of PTEN protein expression in varioliform gastritis was significantly lower than that in chronic superficial gastritis （44.4% vs 92%,χ^2=14.47,P〈 0.01） though no significant difference was noted between varioliform gastritis and gastric cancer （44.4% vs 25.8%,χ^2=2.51,P〉 0.05）.The positive rate of P16 protein expression in varioliform gastritis was significantly lower than that in chronic superficial gastritis （50% vs 96%,χ^2=14.56,P〈 0.01）,but significantly higher than that in gastric cancer （50% vs 19.4%,χ^2=6.80,P〈 0.01）.CONCLUSION：Both PTEN and P16 proteins may be involved in the evolution of varioliform gastritis to gastric cancer.

关 键 词：疣状胃炎 胃癌 PTEN蛋白 P16蛋白 

分 类 号：R573.3[医药卫生—消化系统] R735.2[医药卫生—内科学]