去纤酶对防止家兔实验性动脉粥样硬化斑块形成的作用  

The effect of defibrase in prevention of experimental atherosclerosis in rabbits

作　　者：唐亚辉[1,2] 刘萃[1,2] 李次芬 李维华[1,2] 

机构地区：[1]海军总医院肿瘤血液研究室 [2]解放军总医院西院B超室

出　　处：《中华病理学杂志》1999年第2期112-114,共3页Chinese Journal of Pathology

摘　　要：目的研究去纤酶是否具有防止家兔实验性动脉粥样硬化斑块形成的作用。方法对给药组及对照组模型动物血清总胆固醇含量、主动脉病变面积及胆固醇含量、心壁冠状动脉分支狭窄程度进行定性或定量分析。结果去纤酶能降低血清及动脉壁的胆固醇含量（Ｐ＜０．０１），斑块面积明显小于模型对照组（Ｐ＜０．０１）。在胸腹主动脉区各动脉分支开口斑块形成计数中，给药组明显少于对照组。心脏上１／３处横切片显示心壁内冠状动脉大、中分支的狭窄程度，去纤酶组轻于对照组（Ｐ＜０．０１）。结论去纤酶能有效地抑制动脉粥样硬化斑块的形成和发展。Objective To study the anti atherosclerosis effect of difibrase in rabbits. Methods Use of computor, light microscope, electron microscope, biochemistry and histochemical methods to identify the total cholesterol (TC) content, mean plaque area in aorta and its cholesterol content, degree of stenosis of coronary arteries of the experimental animals and control animals. Results Defibrase could decrease the mean plaque area of aorta and the TC content in the experimental animal group was less than that in the contorl group ( P <0.01). The findings in aortic arches and thoracic aorta were similar to those in the aorta ( P<0.05, P<0.01) The number of plaques at the small artery openings in the thoracic aorta and abdominal aorta of the experimental group were less than that of the control group ( P <0.01). The cross sections made at the upper third of all hearts showed that the degree of stenosis of coronary artery branches in the heart wall of the experimental group was much less than that of the control group. Conclusion Defibrase can significantly inhibit atherosclerosis.

关 键 词：蛇毒 动脉粥样硬化 综合预防 去纤酶 

分 类 号：R543.505[医药卫生—心血管疾病]