联合检测HE4和CA125在卵巢肿瘤中的表达及其临床意义  

The expression and significance of combinated detection HE4 and CA125 in the ovarian carcinoma

作　　者：陆牡丹[1] 陈道桢[2] 赵军[1] 张立[1] 许飞[1] 张婷[1] 

机构地区：[1]南京医科大学附属无锡妇幼保健院检验科,214002 [2]南京医科大学附属无锡妇幼保健院遗传实验室

出　　处：《中国妇幼保健》2010年第25期3623-3625,共3页Maternal and Child Health Care of China

基　　金：国家自然科学基金项目(30872999);江苏省自然科学基金项目(BK2007023);南京医科大学科技发展基金重点项目(09NJMUZ48)

摘　　要：目的:探讨HE4和CA125在卵巢癌中的浓度变化及其临床意义。方法:应用ELISA法检测血清HE4含量,同时应用电化学免疫发光方法检测CA125和CEA在实验对象血清中的浓度。结果:在卵巢恶性病变组中,HE4和CA125的阳性率分别为57.69%和60.25%,在HE4和CA125联合检测中阳性率为80.76%,且HE4和CA125的浓度均与患者腹水转移之间有统计学意义;CEA的浓度与临床病理特征均无统计学意义。结论:HE4在卵巢癌患者中高表达,与卵巢癌的恶性进展相关,可能成为与CA125作为卵巢癌监测的互补指标。Objective：To investigate the variation of HE4 and CA125 concentration in human ovarian carcinoma and its clinicopathologic significance.Methods：ELISA study for HE4 concentration and electrochemistry irradiance study for CA125 and CEA concentration in human ovarian carcinoma.Results：The masculine rate of HE4 and CA125 was 57.69% and 60.25% in the malignant group.While the masculine rate of HE4 and CA125 combinated detection was 80.76%.Furthermore statistics analysis results displayed that the variation of HE4 and CA125 concentration was correlated with ascites（P〈0.05） in total experiment objects.In addition,the CEA concentration was not associated with clinicopathological parameters（P〈0.05）.Conclusion：Expression of HE4 and CA125 are up-regulated significantly in human ovarian carcinoma,and overexpression of HE4 may play an important role in oncogenesis and development of ovarian carcinoma.HE4 may have potential significant indicatrix complementaried with CA125.

关 键 词：卵巢癌 HE4 CA125 

分 类 号：R737.31[医药卫生—肿瘤]