疾病稳定期精神分裂症患者自知力水平与执行功能相关性研究  

The correlation study of insight and execution function of stable phase schizophrenics

作　　者：朱道民[1] 董毅[1] 李晓驷[1] 杨琪[1] 谢思思[1] 季芳[1] 

机构地区：[1]合肥市精神病医院,安徽·合肥230022

出　　处：《临床心身疾病杂志》2010年第5期404-406,共3页Journal of Clinical Psychosomatic Diseases

基　　金：安徽省卫生厅医学科研计划项目资助（编号68068068）

摘　　要：目的 探讨疾病稳定期精神分裂症患者自知力水平与执行功能的相关性,为临床干预提供依据. 方法 对41例有自知力和42例无自知力的疾病稳定期精神分裂症患者、41例健康体检者（对照组）,采用Wisconsin卡片分类测验和自知力与治疗态度问卷进行测评分析. 结果 无自知力组、有自知力组与对照组Wisconsin卡片分类测验总应答数、错误应答数、完成第一个分类所需应答数、持续性错误数、非持续性错误数和概念化水平数评分均有极显著性差异（P＜0.01）;对照组及有自知力组WCST总应答数、错误应答数、完成第一个分类所需应答数、持续性错误数和非持续性错误数评分均显著低于无自知力组（P＜0.05或0.01）,而概念化水平数评分显著高于无自知力组（P＜0.01）;对照组除总应答数、错误应答数显著低于有自知力组（P＜0.05）外,其他项目评分与有自知力组均无显著性差异（P＞0.05）. 结论 精神分裂症患者自知力的缺乏与额叶执行功能损害存在相关.Objective To explore the correlation of insight and execution function of stable phase schizophrenics in order to provide basis for clinical intervention. Methods Evaluations and analyses were conducted 41 stable phase schizophrenics with insight （group A） and 42 ones without （group B） and in 41 healthy examinees （control group） with the Wisconsin Card Sorting Test （WCST） and the Insight and Treatment Attitude of the Questionnaire （ITAQ）. Results There were very signigicant differences in the scores of the WCST total responses, response errors, required responses of completing the 1st categoriy, perseverative errors, non-perseverative errors and levels of conceptualization between patient and control group （P^0.01） ; the scores of the WCST total responses, response errors, required responses of completing the 1st categoriy, perseverative errors and non-perseverative errors were significantly lower （P〈0.05 or 0.01） and those of levels of conceptualization （P〈0.01） in both the control and group A than in B; total responses and response errors were significantly lower in the control than in group A （P〈0. 05）, but there were no significant differences in the other indexes （P〉0.05）. Conclusion The lack of insight of schizophrenic is related to frontal lobe execution function impairment.

关 键 词：精神分裂症 疾病稳定期 自知力 执行功能 Wisconsin卡片分类测验 自知力与治疗态度问卷 

分 类 号：R749.3[医药卫生—神经病学与精神病学]