大叶紫珠草对肾炎血尿模型大鼠尿红细胞和血清IL-1影响  

Impact of Zizhi on urine red cells and serum IL-1 in mice

作　　者：李淑兰[1] 李文慧[1] 刘宝生[1] 

机构地区：[1]北方学院附属第二医院内四科,河北张家口075100

出　　处：《西部医学》2010年第9期1584-1585,1589,共3页Medical Journal of West China

摘　　要：目的探索大叶紫珠草对肾炎模型大鼠尿中畸形红细胞和血清IL-1的影响。方法用远交系健康SD雄性大鼠60只,采用牛血清白蛋白(C-BSA)加完全弗氏佐剂进行肾炎性血尿动物模型塑造(牛血清白蛋白累积用量200mg,C-BSA加完全弗氏佐剂做皮下、肌肉、腹腔、尾静脉、多部位注射共6周),将实验动物随机分为5组:正常对照组、安络血治疗组、紫珠低剂量组、紫珠中剂量组和紫珠高剂量组,定期测定尿畸形红细胞I、L-1水平,探索大叶紫珠草治疗肾炎性血尿的疗效及其作用机理。结果大叶紫珠草和安络血对尿中畸形红细胞和血清IL-1均可使之降低,且紫珠组明显优于安络血组和生理盐水对照组。结论紫珠治疗肾炎模型大鼠血尿疗效肯定。Objective To explore the function of Zizhu on urine red cells and serum IL-1 in mice.Methods Rat models with nephritic blood urine were made by injecting C-BSA in several parts of body.60 rats were divided into five groups,including low,medium,high dosage of Zizhu and Anluoxue grope,compared with model control group.Results The serum level of IL-1 and red cells in urine were significantly decreased after treating by Zizhu.Conclusion Zizhu can cure blood urine in nephritic model rats effectively.

关 键 词：大叶紫珠草 肾炎血尿模型 尿红细胞 血清IL-1 

分 类 号：R-33[医药卫生]