老年人大肠癌组织胃泌素表达及其与血清胃泌素水平的关系  

Relationship between gastrin expression in cancer tissue and serum gastrin level in elderly patients with colorectal cancer

作　　者：牛跃平[1] 崔广林[1] 李青菊[1] 唐芙爱[1] 李振峰[1] 

机构地区：[1]河南医科大学第二附属医院内科

出　　处：《中华老年医学杂志》1999年第2期106-107,共2页Chinese Journal of Geriatrics

摘　　要：目的探讨老年人大肠癌组织中胃泌素表达的临床病理意义及其与血清胃泌素水平的关系。方法对４６例老年人大肠癌、３２例非老年人大肠癌组织胃泌素表达进行免疫组化观察，并用放免法测定其血清胃泌素水平。结果癌组织中胃泌素表达阳性率，老年组４７．８％（２２例），非老年组１８．８％（６例）（Ｐ＜０．０１）；老年组胃泌素的表达与肿瘤分化程度、ＴＮＭ分期、淋巴结转移有关，非老年组未显示这些关系。老年组和非老年组血清胃泌素水平与健康对照组比较差异均无显著性（Ｐ＞０．０５），癌组织中胃泌素的表达不影响血清胃泌素水平（Ｐ＞０．０５）。结论胃泌素在癌组织中的表达可作为老年人大肠癌恶性度的一项指标，其表达对血清胃泌素水平无影响。Objective To investigate the clinicopathologic significance of gastrin expression in cancer tissue and its relation to the serum gastrin level in elderly patients with colorectal cancer. Methods Gastrin expression in cancer tissue was detected immunohistochemically and serum gastrin level was determined by RIA in 46 cases of elderly patients with colorectal cancer and 32 cases of non elderly patients with colorectal cancer. Results The positive rate of gastrin expression in cancer tissue was 47 8% (22 cases) in elderly group, and 18 8% (6 cases) in non elderly group ( P <0 01). Gastrin expression was related to degree of differentiation, TNM stage and lymph node metastasis in elderly group. This relationship was not found in non elderly group. There was no significant difference in serum gastrin level among the elderly group, non elderly group and the normal control group ( P >0 05). The expression of gastrin in cancer tissue was not related to the serum gastrin level ( P >0 05). Conclusions Gastrin expression in cancer tissue can be taken as an index for degree of malignancy in elderly patients with colorectal cancer. Serum gastrin concentration was not influenced by gastrin expression in cancer tissue.

关 键 词：结肠肿瘤 大肠癌组织 老年人 直肠肿瘤 胃泌素类 

分 类 号：R735.34[医药卫生—肿瘤]