人脑胶质瘤组织MMP-2和Ki-67表达及其相关性的初步研究  

Expressions and corelation of MMP-2 and Ki-67 in human gliomas tissues

作　　者：钟喆[1] 何正文[1] 邱元[2] 任年军[1] 高洪波[1] 章凯[1] 

机构地区：[1]湖南省肿瘤医院神经外科,湖南长沙410007 [2]湖南农业大学细胞工程实验室,湖南长沙410128

出　　处：《中华肿瘤防治杂志》2010年第14期1070-1072,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨基质金属蛋白酶(MMP-2)和Ki-67在人脑胶质瘤组织中的表达及两者之间的关系。方法:用免疫组织化学SP法检测38例人脑胶质瘤组织和7例正常人脑组织中MMP-2和Ki-67的表达。结果:正常人脑组织中无Ki-67表达,高度恶性胶质瘤(Ⅲ～Ⅳ级)中MMP-2和Ki-67的阳性表达率显著高于低级别胶质瘤组织(Ⅰ～Ⅱ级),并且两者的表达呈显著正相关性(Ki-67:Ⅲ～Ⅳ级vsⅠ～Ⅱ级,t=-18.889,P=0.002;MMP-2:Ⅲ～Ⅳ级vsⅠ～Ⅱ级,t=4.786,P=0.001;相关性:r=0.661,P=0.001)。结论:MMP-2和Ki-67在恶性胶质瘤组织中高表达,与胶质瘤的进展和侵袭密切相关,可作为胶质瘤恶性表型的有用指标。OBJECTIVE：To investigate the MMP-2 and Ki-67 in human gliomas and their relationships.METHODS：The expressions of MMP-2 and Ki-67 were detected in 38 human glioma tissues and 7 normal human brain tissues with immunohistochemical assay（SP method）.RESULTS：The expressions of MMP-2 and Ki-67 in the patients with high-grade glioma were significantly higher than those in the patients with low-grade glioma and normal brain tissues,and the significant correlation was found between MMP-2 and Ki-67（ Ki-67：grade Ⅲ-Ⅳ vs grade Ⅰ-Ⅱ,t=-18.889,P=0.002;MMP-2：grade Ⅲ-Ⅳ vs grde Ⅰ-Ⅱ,t=4.786,P=0.001;corelation：r=0.661,P=0.001）.CONCLUSIONS：MMP-2 and Ki-67 are overexpressed in malignant gliomas,especially in glioblastoma tissues,and may be involved in the progression and invasion of glioma.It could be regarded as a useful marker for judging the malignant phenotype of glioma.

关 键 词：脑肿瘤 神经胶质瘤 基质金属蛋白酶 

分 类 号：R739.4[医药卫生—肿瘤]