A parallel approach to direct resolution of albuterol  

作　　者：ZHONG QingLin PENG XiaoHua WU TongFei FU FangMin CUI Xin ZHU Jin DENG JinGen 

机构地区：[1]National Engineering Research Center of Chiral Drugs and Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China

出　　处：《Chinese Science Bulletin》2010年第25期2814-2816,共3页

基　　金：supported by the National Natural Science Foundation of China (29790125,29972039 and 20025205)

摘　　要：A library consisting of a series of O,O'-diaryzoyl-L-(-)-tartaric acids (2) was designed and synthesized. The substituent on the aromatic ring of 2 significantly affects the diastereomeric excess and efficiency of the resolution of racemic albuterol (1). Excel-lent resolving reagent 2a was selected for the resolution of rac-1 via the parallel approach. However,a family of three resolving reagents failed to improve the resolution efficiency of rac-1.A library consisting of a series of O, O＇-diaryzoyl-L-（-）-tartaric acids （2） was designed and synthesized. The substituent on the aromatic ring of 2 significantly affects the diastereomeric excess and efficiency of the resolution of racemic albuterol （1）. Excel- lent resolving reagent 2a was selected for the resolution of rac-1 via the parallel approach. However, a family of three resolving reagents failed to improve the resolution efficiency of rac-1.

关 键 词：沙丁胺醇 并行方式 直接解 选择试剂 Excel RAC 脂肪酸 酒石酸 

分 类 号：S859.84[农业科学—临床兽医学] TP273[农业科学—兽医学]