慢性应激与肿瘤关系的研究进展  

Chronic Stress and Cancer Progression

作　　者：沈晶尧[1] 袁爱华[1] 马永[1] 曹红勇[1] 

机构地区：[1]南京医科大学附属南京第一医院普通外科,南京210006

出　　处：《医学综述》2010年第17期2624-2626,共3页Medical Recapitulate

摘　　要：慢性应激是个体面对特殊环境变化而不能调整和稳定内环境稳态时所经历的持续的情感及心理反应。近年来的研究表明,应激通过神经系统启动瀑布式级联效应,神经内分泌介质修饰肿瘤微环境和应激相关神经内分泌介质激活瘤细胞内增殖和转移相关信号通路,从而影响肿瘤的发生、发展和预后。理解慢性应激在肿瘤演进中的作用和机制,有利于设计合理的干预措施治疗肿瘤。Chronic stress is an emotional and physiological reaction experienced by an individual confronting with a situation,in which the demand of adaptation goes beyond their coping resources.Recent studies demonstrated that stress starts the waterfall cascading effect through the nervous system,and neuroendocrine medium modified tumor microenvironment and stress-related neuroendocrine tumor cells activate the relevant signaling pathways responsible for proliferation and metastasis,thus affecting the incidence of tumor development and prognosis.Understanding the mechanisms of action of chronic stress in promoting cancer progression is crucial for devising effective interventions.In this article,we briefly review the recent findings of the relationship and mechanisms between chronic stress and cancer.

关 键 词：慢性应激 神经内分泌介质 昼夜节律 心理疗法 肿瘤 

分 类 号：R73[医药卫生—肿瘤]