男性乳腺癌研究进展  

Research Progress of Male Breast Cancer

作　　者：盛俊秀[1] 田余祥[2] 

机构地区：[1]大连医科大学 [2]大连医科大学生物化学教研室,辽宁大连116044

出　　处：《医学综述》2010年第17期2634-2636,共3页Medical Recapitulate

摘　　要：男性乳腺癌(MBC)是一种罕见的肿瘤,与女性乳腺癌相比,在发病年龄、病程及转移率等方面均有较大的差别。MBC多与分泌异常相关联,如雌激素水平增高、患者雌激素受体和孕激素受体表达水平下降。近年来发现,MBC患者细胞内某些基因出现突变(如BRCA1/2)或表达增高(芳香酶、sur-vivin和环氧化酶2)。MBC患者常有糖链抗原15-3升高,糖链抗原15-3和癌胚抗原联合检测可以提高MBC检出的敏感度。Male breast cancer（MBC）is a rare tumor.In contrast to female breast cancer,MBC exhibits evident differences in age of onset,course of disease,and metastasis rate.In many cases,MBC is related to endocrine abnormality,such as elevated estrogen level and reduced estrogen and progestin receptor expression.In recent years,it has been discovered that certain genes,such as BRCA1/2,have mutations,whereas the expression of other genes,such as aromatase,survivin and COX-2,is commonly increased in MBC cells.The level of carbohydrate antigen 15-3（CA15-3）is elevated in MBC patients.The sensitivity of screening out MBC can be enhanced by the combination assay of CA15-3 and carcinogenic embryo antigen.

关 键 词：男性乳腺癌 病因学 发病机制 诊断与治疗 预防 

分 类 号：R737.9[医药卫生—肿瘤]