生物可降解两亲性嵌段共聚物胶束的制备及其对叶酸的控制释放  

Preparation of amphiphilic biodegradable block copolymer micelle and its controlled release on folic acid

作　　者：刘学军[1] 许博[1] 翟翠萍[1] 袁金芳[1] 高青雨[1] 

机构地区：[1]河南大学精细化学与工程研究所,河南开封475004

出　　处：《胶体与聚合物》2010年第3期99-102,共4页Chinese Journal of Colloid & Polymer

基　　金：国家自然科学基金(50273010);河南大学科研基金(072R2D010)

摘　　要：以甲氧基聚乙二醇(mPEG)为引发剂,在辛酸亚锡催化下引发ε-环己内酯(CL)开环聚合,合成了聚乙二醇-聚己内酯两亲性嵌段共聚物(mPEG-PCL)。通过FTIR、1H-NMR及GPC等表征手段确定了mPEG-PCL的组成及结构。采用芘荧光探针法、透射电镜和动态激光光散射研究了聚合物在水中的自组装行为。结果表明:聚合物在水溶液中能够自组装形成粒径小于100 nm的规则球状胶束,且具有较低的临界胶束浓度(7.35×10-3 g/L);模型药物(叶酸)成功负载于聚合物纳米胶束内,并且能延缓叶酸的释放,其释药速率受载药量和释放介质pH的影响。Amphiphilic block copolymer mPEG-b-PCL was synthesized by the ring-opening polymerization of e-caprolactone（e-CL） employing SnOch as catalyst and methoxypoly（ethylene glycol） （mPEG） as macro-initiator. The structure and molecular weight were characterized by FT-IR, IH-NMR and GPC. The self-assembled behavior in water was studied by pyrene fluorescence probe technique, transmission electron microscopy（TEM） and dynamic laser light scattering（DLS）. The results show that mPEG-b-PCL could self-assemble to form micelle with a low CMC （7.35× 10^-3 g/L）, nano-size （〈100 nm） and regularly spherical in shape in aqueous solution. Model drug folic acid（FA） was incorporated into the micelles, the in vitro drug release characteristics suggested that the drug-loaded micelles could sustain the drug release, and the drug release rate were affected by the drug loading content and the pH of the release media.

关 键 词：两亲性嵌段共聚物 聚合物胶束 药物载体 控制释放 

分 类 号：O631.4[理学—高分子化学]