姜末穴位外敷预防含铂化疗药物介入治疗肝癌及转移性肝癌后恶心呕吐的研究  

Evaluation of point plaster therapy with ginger powder in preventing nausea and vomiting occurred after platinum-based interventional chemotherapy in patients with primary or metastatic liver cancer

作　　者：陆海燕[1] 杨玚[1] 孟志强[1] 陈雷华[1] 

机构地区：[1]上海复旦大学附属肿瘤医院护理部,200032

出　　处：《介入放射学杂志》2010年第8期664-668,共5页Journal of Interventional Radiology

基　　金：复旦大学护理科研基金资助项目(编号:200816)

摘　　要：目的比较姜末穴位外敷加恩丹西酮与单用恩丹西酮在预防含铂化疗药介入后恶心呕吐的效果。方法肝癌患者将接受含铂化疗药物动脉灌注,并且加用恩丹西酮预防恶心呕吐,以姜末(试验组)或安慰剂(对照组)穴位贴敷,采用罗德恶心呕吐指数表对试验组31例和对照组31例肝癌患者进行调查。结果①姜末穴位贴敷可明显降低患者介入治疗后恶心呕吐发生率:介入后0～12、12～24、24～36、36～48、48～60、60～72h试验组恶心、呕吐等方面发生人数明显低于对照组(P<0.05)。48～60h试验组干恶的发生率无显著改善(P>0.05),其他时段干恶发生率明显低于对照组(P<0.05)。②姜末穴位贴敷使得介入后恶心呕吐程度明显减轻:试验组在61～72h时所测得的恶心、呕吐、干恶程度均值为0.45、0.25、0.19,而对照组恶心、呕吐、干恶程度均值分别为:2.77、0.87、0.97(P<0.05)。结论姜末穴位贴敷可明显降低肝癌患者使用含铂化疗药介入后恶心呕吐发生率。Objective To evaluate the point plaster therapy with ginger powder combined with ondansetron hydrochloride in preventing nausea and vomiting usually occurred after platinum-based interventional chemotherapy in patients with primary or metastatic liver cancer,and to compared its effectiveness with that by using ondansetron hydrochloride only. Method Sixty-two patients with primary or metastatic liver cancer,who were scheduled to receive platinum-based interventional chemotherapy,were randomly and equally divided into two groups with 31 cases in each group. The patients in the study group （n = 31） were given point plaster therapy,i.e. externally applying ginger powder （20 g） to the point of Shenque,for four days together with arterial infusion of ondansetron hydrochloride （8 mg） during interventional procedure,while the patients in the control group （n = 31） were given point plaster therapy with placebo （potato powder） together with arterial infusion of ondansetron hydrochloride （8 mg） during interventional procedure. The questionnaire of INVR （index form for evaluating nausea and vomiting） was used to assess the effectiveness,and the results were compared between two groups. Results The incidence of nausea and vomiting in study group was significantly lower than that in control group at all observed points of time during the period of 0 -72 hours after the treatment （P 〈0.05）. The occurrence of retching in study group was significantly lower than that in control group （P 〈0.05） for the whole observed period except for the period from 49 to 60 hours after chemotherapy （P 〉0.05）. After the treatment the scores of nausea,vomiting and retching in the study group were 0.45,0.25 and 0.19 respectively,while these in the control group were 2.77,0.87 and 0.97 respectively,the differences between two groups were statistically significant （P 〈0.05）. Conclusion The external application of ginger powder to points of Shenque can markedly decrease the incidence and severity of

关 键 词：生姜 肝癌 含铂化疗 介入 恶心 呕吐 干呕 

分 类 号：R735.7[医药卫生—肿瘤]