老年隐源性癫癎患者临床特点和生活质量的研究  

Study of clinical characteristics and quality of life in elderly patients with cryptogenic epilepsy

作　　者：耿翔[1,2] 吴逸雯[1] 邓钰蕾[1] 卫国华[1] 陈旭 陈生弟[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院神经内科,200025 [2]上海第八人民医院神经内科

出　　处：《临床神经病学杂志》2010年第4期260-262,共3页Journal of Clinical Neurology

摘　　要：目的研究老年隐源性癫癎患者的临床特点和生活质量。方法采用临床调查表、癫癎患者生活质量量表-31(QOLIE-31)、汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA),对35例老年隐源性癫癎的患者(老年组)和70例青年患者(青年组)进行评定。结果与青年组比较,老年组有发作诱因和服多种药的比率低,有共病的比率高(均P<0.05)。QOLIE-31中在发作担忧和药物影响两个子项目的评价上优于青年组,但老年组总体生活质量与青年组的差异无统计学意义。单因素分析显示性别、发作类型、药物不良反应、发作后不适感、抑郁和焦虑是影响老年组生活质量的因素;多元逐步回归分析显示,对老年组生活质量评分起主要作用的是焦虑和发作后不适感(均P<0.01)。结论老年隐源性癫疒间患者具有发作诱因少、共病多和服单种抗癫疒间药物为主的临床特点。老年患者和青年患者的总体生活质量水平相近。焦虑和发作后不适感是影响老年患者生活质量的重要因素。Objective To investigate the clinical characteristics and quality of life （QOL） in elderly patients with cryptogenic epilepsy.Methods 35 elderly patients （elderly group） and 70 younger patients （younger group） with cryptogenic epilepsy were estimated by using clinical questionnaire,the Quality of Life in Epilepsy Inventory-31 （QOLIE-31）,Hamilton Depressive Scale （HAMD） and Hamilton Anxiety Scale （HAMA）.Results Compared with the younger group,the rate of seizure incentives and took a variety of drugs were lower in the elderly group,and the rate of comorbidity was higher （all P〈0.05）.In QOLIE-31,the scores of seizure worry and medication effects domains were higher in elderly group,but there was no significant difference of general QOL between elderly group and younger group.It was shown that gender,seizure type,adverse effects of medication,discomfort after epileptic seizure,depression and anxiety influenced QOL in elderly group.Multiple stepwise regression analysis revealed that anxiety and discomfort after epileptic seizure were major factors in affect on QOL in elderly group （all P〈0.01）.Conclusions Clinical characteristics in elderly patients with cryptogenic epilepsy are less seizure incentives,more comorbidity and took a single antiepileptic drug in most cases.Level of general QOL is similar in elderly and younger patients.The anxiety and discomfort after epileptic seizure are the important factors in influencing QOL in elderly patients.

关 键 词：癫癎 老年 生活质量 

分 类 号：R742.1[医药卫生—神经病学与精神病学]