Hippo信号通路与肿瘤发生相关性研究进展  

The correlation between Hippo pathway and tumorigenesis

作　　者：李桂兰[1] 张丽[1] 闫华超[1] 

机构地区：[1]聊城大学生命科学学院,山东聊城252059

出　　处：《基础医学与临床》2010年第9期1002-1004,共3页Basic and Clinical Medicine

摘　　要：Hippo信号通路是新发现的生长控制信号通路,能够限制细胞的生长增殖,诱导细胞凋亡,信号通路不能激活或者作用下调有利于肿瘤的发生。信号通路的组成成分中包括多种抑癌基因和一种候选癌基因,其中候选癌基因YAP在多种类型的人类肿瘤中表达异常增加,而RASFF、MER等抑癌基因在一些人类肿瘤细胞系中突变失活或缺失。The Hippo kinase pathway is a newly described growth regulatory pathway and restricts both cell growth and proliferation,as well as to induce apoptosis,the inactivation or deregulation of the pathway might be particularly advantageous to cancer cells.Several tumor suppressor genes and one candidate oncogene have been implicated as members of this pathway,YAP is a candidate oncogene,which is observed to overexpress in several human cancers,and RASSF or MER functions as tumour suppressor gene and loss-of-function mutation of them has been observed in several human cancer cell lines.

关 键 词：Hippo信号通路 抑癌基因 癌基因 癌症 

分 类 号：R730.2[医药卫生—肿瘤]