持久性有机污染物对水生动物芳香烃受体通道的毒理机制及其早期监测(英文)  

Advances on Toxicological Mechanism of AhR Pathway and Early Biomonitoring of Persistent Organic Pollutants (POPs) in Aquatic Animals

作　　者：周海龙[1,2,3] 张林宝[1,3] 廖春阳[1] 韦双双[2] 郑继平[2] 薛钦昭[1] 

机构地区：[1]中国科学院烟台海岸带研究所,烟台264003 [2]海南大学农学院生物技术系,海口570228 [3]中国科学院研究生院,北京100049

出　　处：《生态毒理学报》2010年第1期9-17,共9页Asian Journal of Ecotoxicology

基　　金：Supported by Knowledge Innovation Program of the Chinese Academy of Sciences (No. KZCX2-YW-Q07-05;KZCX2-YW-Q07-04);Yantai Municipal Science and Technology Development Program(No. 2007323);the Science and Technology Bureau of Yantai City(No. 2009164);the Natural Science Foundation of Hainan Province (No. 309010);the Science and Research Programme of Education Department of Hainan Province(No. Hj2009-21)

摘　　要：过去30年,随着工农业的不断发展,由持久性有机污染物(POPs)导致的癌症患者不断增加.目前POPs已广泛存在于水生态系统中,对水生动物的生长发育、种群繁衍、群落结构等产生重要影响.虽然POPs对水生动物的毒理机制非常复杂,但研究表明其毒理机制主要通过芳香烃受体通道(Ah Rpathway)来进行调控.为全面理解水生动物AhR通道中每一个基因在毒理调控过程中的作用,论文从水生动物芳香烃通道的角度详细阐述了POPs的毒理机制,同时对水生动物中POPs的早期监测进行了讨论,最后提出了未来POPs毒理机制研究的发展方向.With the development of industry and agriculture,the case of cancer is incresing gradually in the last thirty years.Considerable part of the cases are caused by persistent organic pollutants（POPs）and some of them belong to the environmental endocrine disruptors.POPs are ubiquitous in the environment,especilly in the aquatic ecosystem which has aroused the extensive attention of the world.The mechanism of POPs toxicology is very complicated,but it is mainly mediated by the aryl hydrocarbon receptor（AhR）pathway in aquatic animals.The overall goal of this review paper is to highlight the toxicological mechanism of AhR pathway that may contribute to a more holistic understanding of each AhR pathway gene behavior in the toxicological process,as well as the early biomonitoring methods of POPs in aquatic animals.Finally,we propose some perspectives for future toxicological mechhanism research of interest.

关 键 词：持久性有机污染物 水生动物 毒理机制 芳香烃受体通道 生物监测 

分 类 号：X171.5[环境科学与工程—环境科学]