肝细胞肝癌组织中CXCL12及其受体CXCR4的表达变化  

Expression and significance of chemokine CXCL12 and CXCR4 in hapetocellular carcinoma

作　　者：喻亚群[1] 陈谦[1] 钱立元[2] 李淑群[1] 梅铭惠[1] 廖维甲[1] 

机构地区：[1]桂林医学院附属医院,广西桂林541001 [2]中南大学湘雅三院

出　　处：《山东医药》2010年第34期15-16,共2页Shandong Medical Journal

基　　金：广西医疗卫生重点科研课题资助项目(200883)

摘　　要：目的观察肝细胞肝癌(HCC)组织中趋化因子CXCL12及其受体CXCR4的表达变化,并探讨其临床意义。方法采用免疫组化SP法检测60例HCC、10例肝硬化和10例正常肝脏组织中的CXCL12、CXCR4蛋白。结果 HCC组织中CXCL12、CXCR4蛋白阳性率(88.3%、53.3%)明显高于肝硬化组织(30.0%、10.0%)及正常肝脏组织(均为0),P分别<0.05、<0.01;HCC组织中CXCR4蛋白表达与肝门淋巴结转移、侵犯门静脉分支、术后复发转移有关(P均<0.05),CXCL12、CXCR4蛋白表达呈正相关(r=0.715,P<0.05)。结论 HCC组织中CXCL12、CXCR4蛋白高表达,二者共同参与了HCC的发生发展,可作为HCC预后评估的标志物。Objective To investigate the expression of chemokine CXCL12 and its receptor CXCR4 in hepatocellular carcinoma（HCC） tissues,and explore its clinic significance.Methods The expression of CXCL12/CXCR4 protein in 60 HCC,10 cirrhotic livers and 10 normal controls were assessed by immunohistochemistry.Results The positive ratio of CXCL12（88.3%） and CXCR4（53.3%） protein were significantly higher in patients with HCC compared to those with cirrhosis（30%、10%） and healthy individuals（0）,P0.05 and 0.01 respectively.CXCR4 expression was significantly related to tumor metastasis,vessel invasion as well as to recurrence and metastasis after operation（P0.05 respectively）.The correlation between CXCL12 and CXCR4 protein present positively related（r=0.715,P0.05）.Conclusion The expressions of CXCL12 and CXCR4 protein increase in HCC tissues.It may have a role in carcinogenesis of HCC,and be a mark for predicting prognosis of patients with HCC.

关 键 词：肝肿瘤 肝细胞肝癌 趋化因子 趋化因子受体 

分 类 号：R575[医药卫生—消化系统]