p53、p16蛋白在52例食管鳞状细胞癌中的表达及其意义  

EXPRESSION OF p53 AND p16 PROTEIN IN 52 CASES WITH ESOPHAGEAL CANCERS AND ITS SIGNIFICANCE

作　　者：廖琼 孙维刚[1,2] 蒲晓冬[1,2] 何丹[1,2] 

机构地区：[1]四川省肿瘤医院病理科 [2]香港大学医学院解剖系

出　　处：《中国癌症杂志》1999年第2期93-95,共3页China Oncology

摘　　要：目的研究ｐ５３、ｐ１６蛋白表达与食管鳞癌生物学行为的关系。方法应用免疫组化链霉素抗生物素蛋白过氧化物酶连结法（ＬＳＡＢ）法检测５２例食管鳞癌ｐ５３、ｐ１６蛋白表达。结果２９例食管鳞癌ｐ５３过度表达，阳性率为５５８％；２１例食管鳞癌ｐ１６阳性，阳性率为４０４％。随着恶性程度增加及病程进展，ｐ５３阳性率逐渐上升，ｐ１６阳性率逐渐下降，两者存在明显负相关。ｐ５３、ｐ１６阳性与组织学分级无关；ｐ５３阳性与浸润深度有关，而ｐ１６阳性与浸润深度无关。ｐ５３、ｐ１６阳性均与淋巴结转移有关。ｐ５３阳性患者死亡率明显高于ｐ５３阴性者，且存活时间短；ｐ１６阴性患者死亡率明显高于ｐ１６阳性者，且存活时间短。结论同时检测食管鳞癌组织ｐ５３、ｐ１６蛋白表达，有助于综合判断食管鳞癌恶性程度、转移潜能和预后。PURPOSE To study the relationship between the expression of p53 and p16 proteins and biologic behavior of esophageal cancer. METHODS Using immunohistochemical LSAB technic the p53 and p16 protein were examined in 52 cases of esophageal cancer. RESULTS 29 cases of esophageal cancer were p53 positive (55.8%). 21 cases of esophageal cancer were p16 positive (40.4%).There was a reciprocity between p53 and p16 expression in esophageal cancer.p53 protein expression was increasing while p16 expression was decreasing in the process of the development of disease. There were close relations between p53 and p16 expression and lymphonode metastases and survival rate,and no relations between p53 and p16 expression and histological grade.However,there were close relations between p53 expression and depth of tumor invasion,and no relations between p16 expression and depth of tumor invasion. CONCLUSION Simultaneous determination of p53 and p16 proteins might be useful in assessing the degree of malignancy,metastatic potential and prognosis of esophageal cancer.

关 键 词：P53 P16 鳞癌 食管肿瘤 表达 

分 类 号：R735.102[医药卫生—肿瘤]