氟尿嘧啶持续滴注及放射治疗胸段食管癌  

CONTINUOUS INTRAVENOUS INFUSION OF FLUOROURACIL BASED CHEMOTHERAPY AND RADIATION IN THE MANAGEMENT OF THORACIC ESOPHAGEAL CANCER

作　　者：戴爱娣[1] 陈文湛[1] 郭文杰[1] 郑秀立[1] 黄富麟[1] 许康雄[1] 

机构地区：[1]江苏省肿瘤医院内科

出　　处：《中国癌症杂志》1999年第2期96-97,共2页China Oncology

摘　　要：目的研究Ⅱ期胸段食管癌采用同时放化疗的可行性、疗效和毒副作用。方法３２例病人第１天开始放疗，６０Ｃｏ食管胸前后二野加三野同中心，每天２００ｃＧｙ，每周５次，总量５８～６６Ｇｙ，病变位于胸上段加双锁骨上预防６０ＣｏＤＴ５０Ｇｙ。化疗：丝裂霉素（ＭＭＣ）６ｍｇ／ｍ２静注第２天；氟尿嘧啶（５ＦＵ）每天１ｇ／ｍ２９６ｈ持续输液泵静滴，第２～５天，第２９～３２天；顺铂（ＤＤＰ）７５ｍｇ／ｍ２静滴，第２９天。结果第二周期全量化疗１７例，１４例因白细胞下降，剂量减半，１例未能完成第二周期化疗。放化疗的有效率为９６８％。同时进行放化疗的毒副作用较单独化疗或放疗增加，但能耐受没出现Ⅳ级毒性。结论本研究取得了近期疗效，说明同时放化疗治疗食管癌是可行的。PURPOSE To study the possibility,effects and toxicity of concurrent chemotherapy and radiation therapy in stage Ⅱ thoracic esophageal cancer. METHODS 32 patients received radiation of 200 cGy 60 Co per day using isocentric irradiation of two to three fields (5 times weekly).Total dosage is 58～66 Gy,prophylactic irradiation of 50 Gy of 60 Co for the bilateral supraclavicular fields was carried out for upper thoracic esophageal cancer. Mitomycin(6 mg/m 2) was administered intravenously on day 2,and 5 FU 1 g/m 2 per day as continous intravenous infusion for 96 hours on day 2～5 and day 29～32,and cisplatin(75 mg/m 2) on day 29 by intravenous infusion. RESULTS 17 patients received full dosage of chemotherapy and 14 received half dosage because of drop in white blood cells.Total response rate was 96.8%.Toxicity was increased in combined chemotherapy and radiation in as compared to simple radiation or chemothrapy.However,patients could tolerate the combined treatment and no Ⅳ grade toxicity occurred. CONCLUSION This study showed good stort term effects while toxicity is not severe,and concurrent radiation and chemotherapy is feasible.

关 键 词：食管癌 氟尿嘧啶 放射疗法 药物疗法 

分 类 号：R735.105[医药卫生—肿瘤]