他莫昔芬与甲孕酮序贯治疗27例晚期子宫内膜腺癌  

SEQUENTIAL COMBINATION OF TAMOXIFEN AND MEDROXYPROGESTERONE ACETATE IN 27 CASES WITH ADVANCED ADENOCARCINOMA OF ENDOMETRIUM

作　　者：姚亚民[1] 赵艳秋[1] 桑玫[1] 

机构地区：[1]河南省肿瘤医院

出　　处：《中国癌症杂志》1999年第2期127-128,共2页China Oncology

摘　　要：目的研究他莫昔芬（三苯氧胺）与甲孕酮序贯治疗晚期子宫内膜腺癌的临床疗效及与疗效有关的因素。方法采用三苯氧胺（２０ｍｇ／ｄ）与甲孕酮（５００ｍｇ／ｄ）序贯治疗晚期子宫内膜腺癌２７例。结果有效率６２９％（１２／２７），完全缓解率２５９％（７／２７），疗效与激素受体情况、复发转移部位密切相关。结论三苯氧胺与甲孕酮序贯治疗晚期子宫内膜腺癌疗效良好，在所用剂量下无明显毒副作用，对生存期、生活质量的改善仍需进一步观察。PURPOSE To study clinical effect of temoxifen and medroxyprogesterone on advanced adenocacinoma of endomatrium,the relationship of clinical effect and relative cause.METHODS 27 cases of advanced adenocarcionma of endometrium were studied with seqential combination of tamoxifen(20mg/d) and medroxyprogesterone acetate(500mg/d).RESULTS The total oljective response rate and complete remission rate were 62.9%(17/27)、25.9%(7/27) respectively,hormone receptor(ER、PR) and metastasis sites were rolevant to obrective response rate.CONCLUSIONS This remedy is effetive for advanced adenocarcinoma of endometrium.No serious side effects were observed at above doses,survivor period and life quality will be supposed to observe in futwre.

关 键 词：他莫昔芬 甲孕酮 子宫内膜癌 药物疗法 

分 类 号：R737.330.5[医药卫生—肿瘤]