Bcl-2癌蛋白在急性髓性白血病的表达  

Bcl 2 PROTEIN EXPRESSION IN ACUTE MYELOID LEUKEMIA

作　　者：李先根[1,2,3] 钟华[1,2,3] 周柱[1,2,3] 邬伟秀[1,2,3] 施达仁[1,2,3] 

机构地区：[1]上海市第一人民医院血液科 [2]上海第二医科大附属仁济医院 [3]上海医科大学附属肿瘤医院

出　　处：《中国癌症杂志》1999年第2期129-131,共3页China Oncology

摘　　要：目的研究Ｂｃｌ２癌蛋白与白血病的发病及预后的关系。方法应用免疫组化的亲和素生物素过氧化物酶复合物（ＡＢＣ法）检测急性髓细胞性白血病（ＡＭＬ）３４例Ｂｃｌ２蛋白表达水平。结果３５例初治ＡＭＬ中，阳性１７例，其中１１例为Ｍ４、Ｍ５患者。外周血白细胞计数高者有高表达。结论白血病患者Ｂｃｌ２癌蛋白的表达与细胞分化、高白细胞计数、单核细胞类白血病等生物学特性有明显相关性，可能作为白血病的预后指标。PURPOSE To investigate the relationship between Bcl 2 protein and acute myeloid leukemia.METHODS Bcl 2 protein expression in cell lines(NB4,HL 60,K562) and 34 AML patients (M 1 6 cases,M 2 7 cases,M 3 7 cases,M 4 7 cases,M 5 7 cases) was achieved by the immunohistochemical method(ABC) RESULTS Bcl 2 protein expression of lines(NB4,HL 60) is down regulation during using ATRA,high expression of Bcl 2 was found in biologic findings such as undifferintation,hyper leukocytosis,monoblastic types AML.CONCLUSION Bcl 2 is frequently detected in AML patients.The increase of Bcl 2 protein is associated with hyperleukocytosis,monoblastic types,which may be used as a possible marker of prognosis in AML patients.

关 键 词：急性白血病 基因BCL-2 癌基因蛋白 基因表达 

分 类 号：R733.710.2[医药卫生—肿瘤]