KAIl／CD82、E-钙黏蛋白与β-连接蛋白在子宫内膜癌组织的表达及意义  

Expression and significance of KAI1/CD82, E-cadherin and 15-catenin in endometrial carcinoma

作　　者：黄筱竑[1] 章彤华[1] 平金良[1] 姚国荣[1] 

机构地区：[1]湖州市中心医院妇产科,浙江省湖州313000

出　　处：《中国基层医药》2010年第16期2171-2173,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 研究KAI1/CD82、E-钙黏蛋白（cadherin）与β-连接蛋白（catenin）在子宫内膜癌组织中的表达及其临床意义. 方法 采用免疫组织化学EnVision二步法检测76例子宫内膜癌、15例非典型增生子宫内膜、20例正常增生期子宫内膜组织中KAI1/CD82、E-cadherin和β-catenin的表达并加以分析. 结果 与非典型增生内膜及正常增生期子宫内膜比较,KAI1/CD82在子宫内膜癌的阳性表达降低（P＜0.01）,E-cadherin与β-catenin在子宫内膜癌的异常表达增高（均P＜0.01）.KAI1/CD82在子宫内膜癌的表达与组织学分级、肌层浸润程度呈负相关（P＜0.05）;E-cadherin在子宫内膜癌的表达与组织学分级及组织学类型有关（P＜0.01,P＜0.05）;β-catenin在子宫内膜癌的异常表达与组织学分级和手术-病理分期呈正相关（P＜0.01,P＜0.05）.KAI1/CD82与E-cadherin、β-catenin的表达有明显的相关性（P＜0.01,P＜0.05）. 结论 KAI1/CD82、E-cadherin和β-catenin表达改变与子宫内膜癌的进展有关;KAI1/CD82的表达下调与E-cadherin和β-catenin的异常表达增高有关.Objective To explore the expression of KAI1/CD82,E-cadherin and β-catenin in endometrial carcinoma,and to investigate their correlations to clinicopathological parameters of endometrial carcinoma. Methods The expressions of KAI1/CD82,E-cadherin and β-catenin in 76 specimens of endometrial carcinoma,15 specimens of atypical endometrial hyperplasia and 20 specimens of proliferative endometrium were examined by immunohistochemical envision technique.Their correlations to clinicopathological parameters of endometrial carcinoma were statistically analyzed. Results Compare to normal proliferative phase endometrium and atypical endometrial hyperplasia,the expression of KAI1/CD82 in endometrial carcinoma was significantly decreased（P 〈0.01）,the abnormal expression of E-cadherin and β-catenin in endometrial carcinoma were significantly higher（all P 〈0.01）.In endometrial carcinoma,the expression of KAI1/CD82 was negative correlated with histological grade and depth of myometrial invasion（P 〈0.01,P 〈0.05）; The abnormal expression of the E-cadherin is related to histological grade and type（P 〈0.01,P〈0.05）; The abnormal expression of β-catenin was positively correlated with histological grade and FIGO stage（P 〈0.01 ,P 〈0.05）.The down-regulation expression of KAI1/CD82 was closely associated with the abnormal expression of E-cadherin and beta-catenin in endometrial carcinoma（P 〈0.01,P 〈0.05）. Conclusion The down-regulation of KAI1/CD82 and the aberrant expression of E-cadherin and β-catenin could be involved in the development of endometrial carcinoma.The loss or reduced expression of KAI1/CD82 was closely associated with the abnormal expression of E-cadherin and β-catenin in endometrial carcinoma.

关 键 词：KAIlCD82 E-钙粘蛋白 Beta-连接蛋白 免疫组织化学 子宫内膜肿瘤 

分 类 号：R737[医药卫生—肿瘤]