重度牙周病患者血清及龈沟液前列腺素E2、白介素1β水平与2型糖尿病肾病的相关性分析  

Correlation of PGE_2 and IL-1β levels in serum and gingival crevicular fluid with diabetic nephropathy in patients with severe periodontal diseases

作　　者：郝涛[1,2] 高琳[1] 阳琰[1] 廖鑫[1] 丁霞[3] 李显文[1] 晏永慧[1] 王小英[1] 

机构地区：[1]遵义医学院附属第一医院内分泌科,563003 [2]浙江省嘉善县第一人民医院 [3]遵义医学院附属第一医院口腔科,563003

出　　处：《中国糖尿病杂志》2010年第9期671-673,共3页Chinese Journal of Diabetes

基　　金：贵州省卫生厅科技基金资助项目(D-276);遵义医学院中青年科技基金资助项目(F-185)

摘　　要：目的研究前列腺素(PG)E_2和白介素(IL)-1β与重度牙周病患者糖尿病肾病(DN)的关系。方法选取64名有2型糖尿病(T2DM)的重度牙周病患者和16名无糖尿病的重度牙周病患者。测定两组血清和龈沟液中的PGE_2和IL-1β,以及24h尿白蛋白(UAlb)排泄量。结果 (1)24hUAlb正相关于血清和龈沟液中PGE_2和IL-1β含量。(2)龈沟液中IL-1β含量是24hUAlb的独立危险因素。结论血清和龈沟液中PGE_2和IL-1β随UAlb排泄率的增加而增加。Objective To study the correlation of PGE2 and IL-1β with diabetic nephropathy in severe periodontal disease. Methods 64 type 2 diabetic patients with severe periodontal diseases（SPD） and 16 SPD subjects without diabetes were enrolled. The 24h urinary albumin,PGE2 and IL-113 in serum and gingival crevicular fluid （GCF）, and IL-1β in GCF were measured. Results （1） The 24h urinary albumin was positively correlated with PGE2 and IL-1β in serum and GCF. （2）IL-1β in GCF was an independent risk factor for 24h UAlb. Conclusions The PGE2 and IL-1β levels of serum and gingival crevicular fluid are significantly increased along with increment of UAER.

关 键 词：糖尿病.肾病 牙周病 前列腺素E2 白介素1Β 

分 类 号：R781.4[医药卫生—口腔医学]