Ki-67在CD117阳性的中、高危险度胃肠道间质瘤中的表达及其意义  

Expression of Ki-67 in moderate and high risk gastrointestinal stromal tumors with CD117 immunoreactive

作　　者：王刚平[1] 郭文君[2] 刘从惠 梁粉花[1] 付青[1] 孙树艳[1] 

机构地区：[1]山东省日照市人民医院病理科,276826 [2]潍坊医学院病理学教研室 [3]山东高等医学专科学校日照校区病理学教研室

出　　处：《肿瘤研究与临床》2010年第9期622-624,共3页Cancer Research and Clinic

摘　　要：目的探讨Ki一67在CD117阳性的中、高危险度胃肠道间质瘤（GIST）中的表达及其临床意义。方法检测Ki-67在CD117阳性的中危险度（GIST）18例、高危险度GIST25例中的表达，与随访结果对照，并与极低危险度和低危险度组33例比较，分析Ki-67指数（LI）与危险度的关系。结果中、高危险度组随访40例，其中26例健在，高危组7例、中危组5例死于GIST，另2例死于其他原因。Ki-67LI〉5％在危险度中、高组与极低和低组间表达差异有统计学意义（P〈0．01），Ki-67 LI还与核分裂象计数（MI）（〉5／50HPF）、肿瘤大小（〉5cm）相关（P〈0．05），与部位无关（P〉0．05）。结论Ki-67LI〉5％与肿瘤大小〉5cm、MI〉5／50HPF一起可作为CD117阳性的GIST中、高危险度的有用评价指标。Objective To study the expression and significance of Ki-67 in gastrointestinal stromal tumors（GIST） with CDl17 immunoreactive. Methods The expression of Ki-67 was detected by SP method in 25 cases of high risk GISTS, 18 cases of moderate GISTS and 33 cases of extremely low and low risk GISTS, which were compared with the follow-up results. The relationship between Ki-67 index （LI） and risk degree was analyzed. Results Forty patients with moderate and high risk GIST were followed-up, including 26 alive, 12 die of GIST and 2 die of other causes. Compared with patients of extremely low and low risk GIST, Ki-67 LI〉5 % was correlated with moderate and high risk cases （P 〈0.01）, meanwhile Ki-67 LI was positively correlated with tumor sizes of 〉5cm and tumor mitotic cell count 〉5/50 HPF, but was not with locations（P 〉 0.05）. Conclusion Ki-67 LI〉5 %, tumor size〉5 cm and tumor mitotic cell count〉5/50 HPF are risk indicator for GIST with CDl17 immunoreactive.

关 键 词：胃肠道间质肿瘤 KI-67抗原 免疫组织化学 

分 类 号：R735[医药卫生—肿瘤]