慢性酒精中毒性神经病血清叶酸研究  

Study of serum folic acid in patients With chronic alcoholic nervous disease

作　　者：苏文华 包礼平[2] 刘澄中[2] 刘桂喜[2] 

机构地区：[1]牡丹江林业中心医院,157011 [2]大连医学院附属一院

出　　处：《脑与神经疾病杂志》1999年第4期201-204,共4页Journal of Brain and Nervous Diseases

摘　　要：目的：探讨维生素缺乏与慢性酒精中毒的关系。方法：应用放射免疫方法对52例慢性酒精中毒性神经病（CAND）患者进行血清叶酸（FA）测定。结果：（1）CAND患者血清FA含量明显降低；（2）外周血象红细胞平均体积（MCV）增大，红细胞平均血红蛋白含量（MCH）和红细胞血红蛋白平均浓度（MCHC）增高；（3）FA治疗后MCV明显缩小。结论：（1）CAND患者FA缺乏可导致神经系统损害和巨幼红细胞性贫血；（2）FA和MCV测定可做为慢性酒精中毒的诊断指标和防治依据。Objective To investigate relationship between deficiencies of vitamins and chronic alcoholism. Methods Serum fclic acid were studied in 52 patients with chronic alcoholic neuvous disease (CAND) by radioimmunoassay. Results (1) The serum folic acid concentration is significantly lower in patients with CAND than in control group. (2) Red blood cell(RBC) count is reduced, Hemoglobin (Hb) is relatively elevated, mean corpusculat volum (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) are elevated in patients with CAND. (3) MCV and Hb is signicantly reduced in patients with CAND after treatment by folic acid for a mouth. Conclusions (1) Folic acid deficiencies can induco megaloblastic anemia in patients with CAND (2) Folate and MCV may be used as diagnostic indices for alcoholism and may furnish reliable evidence of prevention and treatment for alcoholism.

关 键 词：慢性 酒精中毒性 神经病 叶酸 血清 维生素缺乏 

分 类 号：R749.62[医药卫生—神经病学与精神病学] R595.606[医药卫生—临床医学]