脉冲强磁场对小鼠移植性实体瘤的杀伤作用  

Injurious effect of strong impulse magnetic field on implanted solid tumor in mice

作　　者：胡大为[1,2,3] 张国军[1,2,3] 王群 宋志杰[1,2,3] 马卫军[1,2,3] 范志民 刘国津 

机构地区：[1]承德医学院附属医院肿瘤外科 [2]白求恩医科大学病理教研室 [3]白求恩医科大学附属一院肿瘤外科

出　　处：《中华物理医学与康复杂志》1999年第1期29-30,共2页Chinese Journal of Physical Medicine and Rehabilitation

基　　金：河北省卫生厅基金

摘　　要：目的探讨交变脉冲强磁场对肿瘤组织杀伤作用的机理。方法应用交变脉冲强磁场对９０只接种Ｌｏｕｉｓ肺癌的昆明小鼠作杀伤实验研究。对实验组与对照组荷瘤鼠抑瘤曲线、抑瘤率进行检测。结果两组肿瘤生长曲线存在明显差异（Ｐ＜０．０５）。两组肿瘤生长体积和肿瘤重量均存在明显差异（Ｐ＜０．０１）。实验组瘤体积抑制率为５２．９４％，瘤重量抑制率为３７．２４％。结论交变脉冲强磁场对肿瘤细胞具有杀伤和抑制生长作用。Objective To investigate the mechanism of injurious effect of alternating impulse magnetic field on tumor.Methods The killing experiment via alternating impulse magnitic field was carried on 90 Kunming mice inoculated with Louis lung cancer.The tumor suppressing rates and tumor suppressing curves were observed between experimental group and control group.Results Significant differences in tumor growth curve ( P < 0.05 ),tumor mass and tumor volume existed between the two groups( P < 0.01 ).The tumor suppressing rates of tumor volume and mass were 52.94% and 37.24% respectively in the experimental group.The results revealed selective injurious effect and growth suppressing effect of alternating impulse magnetic field on tumor cells.Conclusion Strong alternating impulse magnetic field may be a new therapy for malignant tumors.

关 键 词：肿瘤 实验肿瘤 实体瘤 脉冲强磁场 杀伤作用 

分 类 号：R73－33[医药卫生—肿瘤]