口腔粘膜扁平苔藓患者丙型肝炎病毒感染的初步研究  

A preliminary study of hepatitis C virus infection in the patients with oral lichen planus.

作　　者：黄华锋[1] 

机构地区：[1]南京军区南京总医院口腔科

出　　处：《实用口腔医学杂志》1999年第2期112-114,共3页Journal of Practical Stomatology

摘　　要：目的：了解ＯＬＰ患者ＨＣＶ感染情况，探讨ＨＣＶ感染与ＯＬＰ之间的关系。方法：用全自动生化检测仪，酶联免疫测定及ＰＣＲ法分别测定４１名ＯＬＰ患者和３８名对照者外周血ＳＧＰＴ、ＳＧＯＴ、抗－ＨＣＶ和ＨＣＶ－ＲＮＡ。结果：４１名ＯＬＰ患者中，１５人（３６．６％）有肝酶异常升高、１２人（２９．３％）抗－ＨＣＶ阳性，１０人（２４．４％）ＨＣＶ－ＲＮＡ阳性；而３８名对照组中，６人（１５．８％）有肝酶异常升高，３人（７．９％）抗－ＨＣＶ阳性，３人（７．９％）ＨＣＶ－ＲＮＡ阳性，ＯＬＰ组的上述三项指标均较对照组为高（Ｐ＜０．０５、Ｐ＜０．０１、Ｐ＜０．０５），两组存在明显的差异。结论：国人ＯＬＰ患者存在较高的ＨＣＶ感染率，表明有相当部份的ＯＬＰ患者体内有ＨＣＶ存在与复制，ＯＬＰ的发病可能与此有一定的关系。Objective:To investigate the infectious condition of hepatitis C virus (HCV) in the patients with oral lichen planus (OLP) and to study the relationship between OLP and HCV infection.Methods:The SGPT,SGOT,anti HCV antibodies and HCV RNA in the serum samples of the 41 OLP patients and 38 controls were examined respectively by the auto biochemical assay,enzyme immunoassay (EIA) and polymerase chain reaction(PCR).Results:In the 41 OLP patients and 38 controls,15(36.6%) patients and 6(15.8%) controls had abnormal liver transaminase level ( P <0.05);12(29.3%) and 3 (7.9%) positve anti HCV antibodies ( P <0.01);10(24.4%)and 3(7.9%)positive HCV RNA( P <0.05);Conclusion:OLP patients have a high HCV infection rate.OLP might be related to the existence and reproduction of HCV to a certain extent.

关 键 词：口腔粘膜疾病 扁平苔藓 丙型肝炎病毒 感染 

分 类 号：R781.54[医药卫生—口腔医学] R512.63[医药卫生—临床医学]