糖化血红蛋白水平与急性脑卒中发病的相关性研究  

The correlation research of the average blood glucose level in patients and the incidence of acute stroke

作　　者：葛庆波[1] 罗巧云[1] 李静[1] 方昭庚[1] 王真真[1] 刘志红[1] 

机构地区：[1]中国人民解放军第458医院神经内分泌科,广东广州510602

出　　处：《中华疾病控制杂志》2010年第7期597-599,共3页Chinese Journal of Disease Control & Prevention

摘　　要：目的探讨急性脑卒中患者与正常对照组血液中糖化血红蛋白(HbA1c)水平的差异,脑卒中组不同病情严重程度患者血中HbA1c含量的差异,以及影像学中脑卒中病灶数与HbA1c含量间的关系。方法选取273例发病1周内的急性脑卒中患者,入院后予以神经功能缺损程度评分、测静脉血中HbA1c水平及颅脑磁共振(MRI)检查。同时对219名健康体检者查HbA1c、葡萄糖耐量实验、颅脑MRI。结果急性脑卒中患者HbA1c水平与对照差异有统计学意义(P<0.05);不同脑卒中病情严重程度组间的HbA1c水平存在一定的统计学差异;磁共振检查中不同的脑卒中病灶数组别间的HbA1c差异有统计学意义(P<0.05)。结论 HbA1c水平是预测脑卒中事件发生、病情严重程度评估的一个重要指标,积极控制高血糖、降低HbA1c水平,有助于减少脑卒中事件的发生,对大规模人群的脑卒中预防具有现实意义。Objective To investigate the blood glycosylated hemoglobin（HbA1c） level between the acute stroke patients and normal control group,the HbA1c level among stroke patients with different severity,as well as the relationship between HbA1c and imaging of cerebral lesions in number.Methods 273 patients of acute stroke were selected within one week.After admission,score of the degree of neurological deficit were evaluated,the HbA1c level were tested in the next day and brain MRI were taken after 48 hours onset.At the same time,HbA1c,glucose tolerance test and brain MRI were performed among 219 healthy persons.Results There was significant difference（P0.05） in HbA1c levels between patients with acute stroke and the control group,as well as patients with different stroke severity and different number of cerebral lesions.Conclusions HbA1c level is an important index for prediction of stroke events and the assessment of disease severity.Proper control of blood sugar,HbA1c levels is important for the prevention of stroke.

关 键 词：糖化血红蛋白 卒中 糖尿病 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R587.1[医药卫生—临床医学]