正交试验优化妇康片的提取工艺  

Optimization of Extraction Process for Fukang Tablets with Orthogonal Design

作　　者：袁勇[1,2] 王鲁妹[1] 张永军[1,2] 王新春[1,2] 

机构地区：[1]石河子大学药学院,新疆石河子832002 [2]石河子大学医学院一附院,新疆石河子832002

出　　处：《中国实验方剂学杂志》2010年第12期19-22,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:优选妇康胶囊的最佳提取工艺。方法:采用正交试验设计,分别以蛇床子素、盐酸小檗碱提取率和浸膏收率为指标,优化黄连、蛇床子等6味药材的提取工艺;以没食子酸提取率和浸膏收率为指标,优选没食子等4味药材的提取工艺。结果:6味药材最佳提取工艺为:10倍量70%乙醇回流提取2次,每次1 h;没食子等4味药材最佳提取工艺为:10倍量水煎煮3次,每次1 h;结论:优选的提取工艺稳定、可行。Objective： To optimize the extraction process of Fukang tablets.Method： Orthogonal design was used to optimize the extracting process of six herb medicines with the extract yield,the content of berberine hydrochloride and osthole as index;to optimize the extracting process of gallic and other two herb medicines with the extract yield and the content of gallic acid as index.Result： The optimum extraction progress was as follows：six herb medicines were extract 2 times for 1 hour with 10 times of 70% alcohol;gallic and other three herb medicines were extract 3 times for 1 hour with 10 times of water.Conclusion： The optimum extraction process was stable and feasible.

关 键 词：盐酸小檗碱 蛇床子素 没食子酸 正交试验 

分 类 号：R283.6[医药卫生—中药学]