九味镇心颗粒治疗广泛性焦虑障碍的Ⅳ期临床研究  

Phase Ⅳ study of the efficacy of Jiuweizhenxin Granula in the treatment of general anxiety disorder

作　　者：胡俊[1] 吴军[1] 林志坚[1] 周芬莉[1] 林凯华[1] 陈涓涓[1] 童晓欣[1] 张季声[1] 易黎[1] 邹文[1] 王春安[1] 张海鸥[1] 

机构地区：[1]北京大学深圳医院神经内科,广东深圳518036

出　　处：《中风与神经疾病杂志》2010年第7期628-630,共3页Journal of Apoplexy and Nervous Diseases

摘　　要：目的观察九味镇心颗粒治疗广泛性焦虑障碍的临床疗效和安全性。方法采用随机开放对照设计,将80例广泛性焦虑障碍患者按随机分入九味镇心颗粒组和九味镇心颗粒合并阿普唑仑组,治疗4w,观察其临床疗效和安全性。结果九味镇心颗粒组(32例)总有效率为90.63%;九味镇心颗粒合并阿普唑仑组总有效率94.12%。不良反应发生率5%。结论九味镇心颗粒用于治疗广泛性焦虑障碍疗效显著,安全有效。Objective To observe and evaluate the efficacy and safety of Jiuweizhenxin granula in the treatment of general anxiety disorder. Methods In a randomized,double blind and parallel-controlled clinical trial,80 patients with general anxiety disorder were recruited. Jiuweizhenxin granula or Jiuweizhenxin granula plus Alprazolam were administered randomly to two groups of patients for 4 weeks. Results The overall response rate was 90.63% for Jiuweizhenxin granula （n=32） and 94.12% for Jiuweizhenxin granula plus Alprazolam （n=34）. There was 5% incidence rate of adverse events. Conclusion Jiuweizhenxin granula is effective and safe to be used in the treatment of general anxiety disorder.

关 键 词：广泛性焦虑障碍 心脾两虚证 九味镇心颗粒 阿普唑仑 

分 类 号：R749.72[医药卫生—神经病学与精神病学]