β-胡萝卜素对氟致大鼠脂质过氧化作用的影响  

Effect of β Carotene on Lipid Peroxidation Induced by Fluoride

作　　者：邱立岩[1] 孙贵范[1] 李革新[1] 丁桂英[1] 

机构地区：[1]中国医科大学公共卫生学院

出　　处：《中国公共卫生》1999年第4期297-299,共3页Chinese Journal of Public Health

基　　金：辽宁省科委科研基金

摘　　要：采用体外大鼠肝微粒体系统和体内经饮水加氟（１５０ｍｇ／Ｌ），同时给予β－胡萝卜素的实验研究方法，研究抗氧化剂β－胡萝卜素对氟所致脂质过氧化作用的影响。体外实验结果表明，加氟可使微粒体系统脂质过氧化物（ＬＰＯ）含量显著增加（Ｐ＜０．０１），同时加入β－胡萝卜素可拮抗氟致微粒体系统的脂质过氧化作用；体内实验结果表明，饮水加氟（１５０ｍｇ／Ｌ）可使大鼠血清、肝、肾组织中ＬＰＯ含量显著增加（Ｐ＜０．０１）；全血及心、肝、肾组织谷胱甘肽（ＧＳＨ）含量明显下降（Ｐ＜０．０１）；全血、肾组织中谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）含量明显下降（Ｐ＜０．０１）；饮氟水同时给予β－胡萝卜素可拮抗上述作用。The effect of β carotene on lipid peroxidation of rat induced by fluoride in vitro and in vivo was studied by rat liver microsomal system and by adding fluoride(150m/L) to drinking water.In virtro the experimental results showed that fluoride could signkficantly increase the content of lipid perxide (LPO) of rat liver microsomal system,and the lipid peroxidation was antagonized by adding β carotene to rat liver microsomal system simultaneously.In vivo the experimetal results showed that the LPO levels of serum,liver,kindney and heart increased and the GSH Px and GSH levels decreased in the simple fluoride treated group.This suggested that the ability of the anti oxidation in fluoriosed rats declined.The LPO level of the body was much lower than the functon of anti oxidation was considerably improved by adding β carotene.

关 键 词：Β-胡萝卜素 微粒体 脂质过氧化 

分 类 号：R977.21[医药卫生—药品]