原发性皮肤CD30+间变大细胞淋巴瘤6例病理分析  

Clinicopathologic analysis of primary cutaneous anaplastic large cell lymphoma in 6 cases

作　　者：赵冬梅[1] 

机构地区：[1]河南省肿瘤医院病理科,郑州450003

出　　处：《临床医学》2010年第8期25-26,共2页Clinical Medicine

摘　　要：目的探讨原发性皮肤CD30+间变大细胞淋巴瘤(C-ALCL)的临床病理特征、免疫表型及预后,提高对C-ALCL的认识和病理诊断水平。方法对6例C-ALCL进行临床病理分析及免疫组化染色。结果 6例中男性3例,女性3例,中位年龄45岁。以皮肤结节为主要临床表现。组织学上具有间变大细胞淋巴瘤的形态特征,瘤细胞体积大,有明显的多形性和异形性,免疫组化6例瘤细胞弥漫表达CD30+,2例ALK+,3例EMA+,T细胞标记可有CD3、CD4、CD45RO或TIA-1的表达,均不表达CK、CD20、S-100、HMB45。结论 C-ALCL少见,掌握其形态学及免疫组化特点对诊断、鉴别诊断及预后具有重要意义。Objective To investigate the clinicopathologic features,immunohistochemical findings of primary cutaneous anaplastic large cell lymphoma（C-ALCL）.Methods Six cases of C-ALCL were enrolled into the study,the clinicopathologic features,immunohistochemical findings were analyzed.Results There were 3 males and 3 females,median age was 45 years.C-ALCL often presented with solitary skin nodule.Histologically,the lymphoma cells were infiltrated the dermis and subcutis in a sheet-like patter.They were of large size and showed conspicuous nuclear atypia.Immunohistochemical study showed the lymphoma cells were positive for CD30,ALK was noted in 2,and EMA in 3.CD3,CD4,CD45RO or TIA-1 were positive.CD20,S-100,HMB45,CK were negative.Conclusion C-ALCL was rare,it is helpful in diagnosis,differential diagnosis and prognosis for C-ALCL by understanding clinicopathologic and immunophenotypic features.

关 键 词：皮肤间变性 淋巴瘤 大细胞 临床病理学特征 免疫组织化学 

分 类 号：R739.5[医药卫生—肿瘤]