异体脱细胞真皮基质修复黏膜缺损的研究  

Acellular dermal matrix allograft to repair the defect of oral mucosa

作　　者：蔡华雄[1] 潘朝斌[1] 李劲松[1] 宋洁文[2] 程慧琳[1] 

机构地区：[1]中山大学附属第二医院口腔科,广州510120 [2]广州市第八人民医院口腔科

出　　处：《中华实验外科杂志》2010年第9期1333-1334,共2页Chinese Journal of Experimental Surgery

基　　金：广东省科技计划资助项目（2007B031000001）

摘　　要：目的 应用异体脱细胞真皮基质（ADM）移植修复口腔扁平苔藓（OLP）切除术后的创面,观察手术方法治疗OLP的临床效果.方法 病变局限于口腔黏膜的OLP患者19例,手术切除病变组织,黏膜缺损区即刻移植ADM,随访时间20～36个月,平均30个月.结果 19例患者中,2例失访;9例痊愈,未见病损复发;5例好转,部分区域OLP病损复发,但复发病损出现在术区外侧缘;3例无效,移植区内病损复发.有效率为73.7%.结论 手术切除OLP病变组织后移植ADM是治疗OLP的新途径,OLP的发病可能与口腔黏膜局部因素有关.Objective To evaluate the clinical use and effect of acellular dermal matrix （ADM） in the repair of the defect of oral mucosa after operation of oral lichen planus （ OLP）. Methods Ninety cases of OLP were treated surgically and the mucosa defect was repaired by ADM allograft immediately. All patients were followed up at mean 30 months （20-36 months） , and clinical examination was conducted to follow up the healing of the ADM graft. Results Two patients were lost follow-up. Nine were well repaired by ADM. Five patients were improved, and the new OLP was found outside the graft region. Three patients were failed, and the new OLP was found inside the graft region. The total success rate was 73. 7%. Conclusion Surgical repair of OLP cases with ADM allograft gave satisfactory results although being a relatively new method of treatment. The result indicated that the occurence of OLP may be come from the change of oral mucosa itself.

关 键 词：脱细胞真皮 移植 口腔黏膜 口腔扁平苔藓 

分 类 号：R781.5[医药卫生—口腔医学]