脑白质疏松患者的认知功能改变  

Study on cognitive function in patients With leukoaraiosis

作　　者：解新荣[1] 曹莹[1] 

机构地区：[1]兰州军区乌鲁木齐总医院老年病科,乌鲁木齐830000

出　　处：《临床医学》2010年第9期11-12,共2页Clinical Medicine

摘　　要：目的研究脑白质疏松(LA)患者的认知功能。方法应用事件相关电位(ERP)、老年认知功能量表(SECF),对34例LA患者进行检测评估,并与性别、年龄和文化程度方面相匹配的34例对照进行对比。结果 LA患者的P3潜伏期明显延长;有明显的记忆障碍;有注意力、注意集中能力、信息提取能力的下降;有时间、空间定向障碍;空间结构能力下降。结论 LA患者有多项认知功能障碍,尤以记忆损害突出;认知功能损害可能与脑室周围低灌注和缺血性损伤有关。Objective To investigate the change of cognitive function in patients with leukoaraiosis（LA）.Methods Thirty-four patients with LA and 34 controls,who matched in sex,age and education,had been tested with events related potential（ERP）,the scale of elderly cognitive function（SECF）.Results The peak latencies of P3 components of ERP in the patients were significantly delayed as compared with the control group.There was significant impairment of memory,attention/concentration,capability of acquiring information and space structure,and directional disorder in time and space in the patients.Conclusion Patients with LA had various impairment of cognitive function,especially in memory.Impairment of cognitive function was related with cerebral blood flow decreased hypoperfusion and ischemia in periventricular white matter.

关 键 词：脑白质疏松 认知功能 

分 类 号：R742.89[医药卫生—神经病学与精神病学]