肝穿刺标本诊断转移性实性假乳头状肿瘤1例报道及文献复习  

Core needle biopsy diagnosis of liver metastatic solid-pseudopapillary tumor:a case report and review of literature

作　　者：张晓玲[1,2,3,4] 孙宇[1,2,3] 汪宁[1,2,5] 李向红[1,2,3] 

机构地区：[1]北京大学临床肿瘤学院 [2]北京肿瘤医院 [3]北京市肿瘤防治研究所恶性肿瘤发病机制及转化研究教育部重点实验室病理科,北京100142 [4]沧州市中心医院病理科 [5]北京市肿瘤防治研究所恶性肿瘤发病机制及转化研究教育部重点实验室影像科,北京100142

出　　处：《诊断病理学杂志》2010年第4期278-280,共3页Chinese Journal of Diagnostic Pathology

基　　金：北京市科技新星计划项目(2005B-44)资助

摘　　要：目的分析实性假乳头状肿瘤(SPT)伴肝转移的临床病理特点,提高对该病的认识。方法对1例肝穿刺标本诊断实性假乳头状肿瘤的临床资料、镜下观察及免疫组化结果进行分析。结果组织学:肿瘤有实性区、囊性区及假乳头区,假乳头区肿瘤细胞围绕血管周围排列,以纤细的纤维血管为轴心形成假乳头结构。肿瘤细胞中等大小,较一致,胞质嗜酸或空泡状,细胞核圆形、卵圆形,可见核沟,有轻度异型性。免疫组化:α1-AT、α1-ACT、CD56、Syn、CD10β-catenin和cyclin D1(+),hepatocyte和E-cadherin(-)。结论肝穿刺标本可以诊断少见的转移性SPT,免疫组化检测对诊断具有重要意义。Objective To study clinicopathologic features of liver metastatic solid-pseudopapillary tumor （SPT）. Methods One case of core needle biopsied liver metastatic SPT was assessed with clinical, pathological and immunohistochemical analysis. Results Histologically, the tumor had solid and pseudopapillary architecture with tumor cells of uniformed size showing slight nuclear pleomorphism. Pseudopapillary structure with a fibrovaseular core was quite remarkable. Immunohistochemically, tumor cells were positive for cd-AT, txl-ACT, CD56, Syn, CD10, [3-catenin, eyclinD1, while hepatocyte and E-cadherin were negative. Conclusion With the help of immunohistochemistry, it is possible to make definite diagnosis of rare metastatic SPT on the core needle biopsy of the liver.

关 键 词：实性假乳头状肿瘤 肝转移 粗针穿刺 

分 类 号：R735.7[医药卫生—肿瘤]