12-脂氧化酶与糖尿病视网膜病变的相关性  

Relationship between 12-lipoxygenase and diabetic retinopathy

作　　者：李倩[1] 王桂云[1] 左玲[1] 

机构地区：[1]吉林大学第二医院眼底病二科,吉林省长春市130041

出　　处：《眼科新进展》2010年第9期887-889,893,共4页Recent Advances in Ophthalmology

基　　金：吉林省科技发展计划基金资助(编号:200705231)~~

摘　　要：糖尿病视网膜病变是糖尿病微血管病变的严重眼部并发症,当前研究认为视网膜的炎症损伤在糖尿病视网膜病变早期发挥重要作用。12-脂氧化酶是一种多元不饱和脂肪酸的氧化酶,其最终过氧化产物为12-羟基二十碳四烯酸。研究证明,12-羟基二十碳四烯酸可以上调血管紧张素II的水平,参与白细胞淤滞、毛细血管周细胞凋亡,导致慢性氧化应激,影响视网膜新生血管的形成。上述改变均是糖尿病时视网膜发生病理改变的重要环节。本文主要综合近年来国内外研究成果,详述12-脂氧化酶对糖尿病视网膜病变早期微血管病变发生的影响。Objective Diabetic retinopathy（DR） is one of the severe complications of diabetic capillary decreases.Many recent studies support the hypothesis that the retinal inflammatory plays an important role in the early stages of DR.12-Lipoxygenase is a member of lipoxygenases family which can oxygenate polyenoic fatty acids to the form of 12-hydroxyeicosatetraenoic acid,which can up-regulate the level of angiotensin II,participating in the leukostasis,pericapillary cells apoptosis,inducing the chronic oxidative stress and influencing the retinal neovascularization.All of these changes are major processes involved in the pathogenesis of diabetic retinopathy.This article reviews the effect of 12-lipoxygenase on the retinal capillary decreases in the early stages of DR based on the up-to-date international research achievements.

关 键 词：12-脂氧化酶 糖尿病视网膜病变 肾素-血管紧张素系统 12-羟基二十碳四烯酸 氧化应激 

分 类 号：R774.1[医药卫生—眼科]