肝硬化腹水患者血清CA125水平的变化分析  

The Analysis on the Change of Serum CA125 Level in Patients with Cirrhotic Ascites

作　　者：张乐刚[1] 高风至[1] 褚瑞海[2] 贾德兴[2] 武超玉[1] 赵博[1] 

机构地区：[1]潍坊医学院内科学教研室,山东潍坊261053 [2]潍坊医学院附属潍坊市人民医院传染科

出　　处：《潍坊医学院学报》2010年第3期219-220,共2页Acta Academiae Medicinae Weifang

摘　　要：目的探讨血清癌抗原CA125水平变化在肝硬化腹水患者中的临床意义。方法肝硬化住院患者70：例,55例伴有腹水，15例不伴腹水，根据Child-Push积分法分为A级2蛰倒，B级。24倒，C级18例，根据B超下测定的液体暗区的深度将腹水分为大量、中量及少量，设正常对照组30例，均为来我院体检的健康者，肝硬化患者治疗前后静脉采血，分离血清，应用化学发光法检测血清CA125。结果血清CA125〉35U／ml为阳性，70例肝硬化患者中67例阳性，55例肝硬化伴腹水患者均为阳性。肝硬化患者血清CA125水平显著高于正常对照组，并随着肝硬化程度的加重而进行性升高。伴有腹水患者血清CA125水平与同一Child—Pugh分级的无腹水患者相比明显升高，并随着腹水量的增加其CA125水平呈逐渐升高趋势。结论肝硬化腹水患者血清CA125多升高，其水平可作为评判肝功能损害程度的指标之一，并对预测腹水的再发生率有一定的价值。Objective To explore the clinical significance of the change of serum CA125 level in patients with cirrhotic ascites. Methods The serum CA125 level was detected in patients with liver cirrhosis （ n = 70 ） and healthy people（ n = 30）. Results Serum CA125 level was significantly higher in patients with cirrhosis than that of the healthy people, and its level gradually increased with the cirrhosis aggravated. Conclusion Serum CA125 was elevated in most patients with cirrhotic ascites, and it may be used as an index for hepatic impairment.

关 键 词：CA125 肝硬化 腹水 血清 

分 类 号：R575.2[医药卫生—消化系统]