乳腺肿瘤超声彩色像素密度及造影增强强度与微血管密度相关性对比分析  

Correlation Between Sonographic Color Pixel Density or Contrast-enhanced Sonographic Enhancement Intensity and Pathologic Microvessel Density of Breast Neoplasms

作　　者：江泉[1] 张渊[1] 张新书[2] 王玲[2] 张超学[2] 

机构地区：[1]浦东新区人民医院超声科,上海市201200 [2]安徽医科大学第一附属医院超声科

出　　处：《中国超声医学杂志》2010年第9期788-790,共3页Chinese Journal of Ultrasound in Medicine

基　　金：上海市浦东新区社会发展局卫生科技资助项目(No.PWZXK2007-02)

摘　　要：目的对比分析乳腺肿瘤超声彩色像素密度、超声造影增强强度与病理切片微血管密度相关性。方法对56例乳腺肿瘤患者,进行超声检查,获得超声多普勒彩色像素密度、超声造影增强强度,术后病理标本CD34免疫组化染色,检测微血管密度。结果乳腺肿瘤恶性组的超声造影增强强度EI、彩色多普勒彩色像素密度CPD及微血管密度MVD高于良性组(P<0.01),EI、CPD与MVD均呈正相关,其偏相关系数分别为分别r_(CPD)=0.576、P=0.005,r_(el)=0.886、P=0.000。结论与超声多普勒彩色像素密度相比,超声造影增强强度与微血管密度有更高的相关性,能更客观评估乳腺肿瘤血管生成。Objective To observe the correlation sonographic color pixel density （CPD） or contrast-enhanced sonographic enhancement intensity （EI） and pathologic microvessel density （MVD） of breast neoplasms. Methods Contrast-enhanced sonography was performed in 56 women with breast neoplasms before surgery. Sonographie color pixel density and contrast-enhanced sonographic enhancement intensity was analyzed. MVD was calculated in surgical specimens after immunohistochemical staining using anti-factor CD34. Results There showed correlation between CPD/EI and MVD（rCPD=0. 576,P=0. 005,rEI =0. 886,P-0. 000）. Conclusions El is of significantly higher correlation with MVD when compared with CPD. EI provides a more valuable noninvasive measure method in breast tumor neovascularity.

关 键 词：乳腺肿瘤 超声检查 造影剂 微血管密度 

分 类 号：R737.9[医药卫生—肿瘤]