焦虑和抑郁情绪对妇科肿瘤患者细胞免疫功能的影响  

A study on depression and anxiety and cell immunity in patients with genital cancers

作　　者：茅伟[1] 邱慧敏[1] 余根培[1] 钱红[1] 王辉[1] 许青[1] 

机构地区：[1]同济大学附属第十人民医院肿瘤内科,上海200072

出　　处：《同济大学学报（医学版）》2010年第4期98-101,共4页Journal of Tongji University(Medical Science)

摘　　要：目的探讨焦虑、抑郁对妇科肿瘤患者细胞免疫的影响。方法采用Zung抑郁自评量表和焦虑自评量表测定67例妇科肿瘤患者的焦虑反应、抑郁反应,并测定其CD3^+、CD4^+、CD8^+、CD4^+/CD8^+比值、NK细胞、TNF、IL-2、IL-6。结果焦虑、抑郁在妇科肿瘤患者中的发生率较高。单纯焦虑障碍、单纯抑郁障碍和焦虑合并抑郁障碍的患者CD3^+、CD8^+、NK细胞、IL-2显著低于无抑郁焦虑障碍的患者,而CD4^+/CD8^+、IL-6显著高于无抑郁焦虑障碍的患者(P<0.05)。焦虑合并抑郁的患者CD3^+、CD8^+、NK细胞、IL-2、TNF显著低于单纯焦虑和单纯抑郁障碍的患者,而CD4^+/CD8^+、IL-6显著高于单纯焦虑和单纯抑郁障碍的患者(P<0.05)。单纯焦虑的患者CD8^+、NK细胞显著低于单纯抑郁障碍的患者,而TNF却显著高于单纯抑郁障碍的患者(P<0.05)。结论焦虑、抑郁反应可导致妇科肿瘤患者细胞免疫功能损害。焦虑合并抑郁反应对妇科肿瘤患者的细胞免疫功能的损害较单纯焦虑和单纯抑郁反应更加严重。Objective To study whether or not depression and anxiety affect cell immunity in patients with genital cancers. Methods Depression and anxiety disorders were determined by using SAS and SDS of ZUNG in 67 female genital cancer patients. The number of cells positive for CD3, CD4, CD8 and the number of NK cells were examined by flowcytometry analysis. The amount of TNF, IL-2 and IL-6 in the periphery blood were measured by RIA. Results The occurrence of depression and anxiety in genital cancer patients was 64. 2% （43/67）, significantly higher than that of normal subjets （P 〈 0.05 ）. The cells positive for CD3, CD8 and NK cells as well as the serum contents for IL-2 and TNF were significantly decreased than those of controls （ P 〈 0.05 ）. On the other hand, the ratio of CD4 versus CD8 and the serum contents of IL-6 were higher than those in controls （P 〈 0.05 ）. Similar trends were also found between patients with anxiety together with depression and patients with depression only or with anxiety only. The cells positive for CD8 and NK cells in anxiety patients were significantly decreased than those in depression patients, but the serum contents of TNF was significantly higher. Conclusion The study indicates that anxiety and depression of psychological stress may impact cell immunity in patients with the female genital cancers. And patients suffered anxiety together with depression demonstrate that more cell immunity is compromised than patients with either anxiety or depression alone.

关 键 词：妇科肿瘤 抑郁 焦虑 细胞免疫 

分 类 号：R737.3[医药卫生—肿瘤]