非小细胞肺癌中p33^(ING1b)表达的临床意义  

Clinical and biological significance of expression of p33^(ING1b) in non-small cell lung cancer

作　　者：范大平[1] 陈艳昕[2] 刘晓民[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院呼吸内科,黑龙江哈尔滨150001 [2]秦皇岛市第一医院病理科,河北秦皇岛066000

出　　处：《哈尔滨医科大学学报》2010年第4期352-354,357,共4页Journal of Harbin Medical University

摘　　要：目的探讨p33^(ING1b)的表达与非小细胞肺癌(non-small cell lung carcinoma,NSCLC)临床病理特征的关系及其在NSCLC发生、发展中的可能作用机制。方法用免疫组化法检测NSCLC和非肿瘤肺组织中p33^(ING1b)的表达。结果 p33^(ING1b)在NSCLC组织中表达率显著低于正常肺组织(P<0.05)。p33^(ING1b)低表达与肺癌的分化、分期及淋巴结转移有关。p33^(ING1b)的表达率在低分化组(29.2%)显著低于高、中分化组(62.5%)、在Ⅲ-Ⅳ期和有淋巴结转移组的表达率显著低于Ⅰ-Ⅱ期和无淋巴结转移组(P<0.05)。结论 p33^(ING1b)在NSCLC中低表达,它的低表达对判断NSCLC恶性程度、浸润甚至转移有重要价值。Objective To explore the relationship between p33^ING1b expression and clinicopathologic characteristics of non-small cell lung carcinoma（ NSCLC ）and the possible mechanism of p33^ING1b in the oncogenesis of NSCLC. Methods Immunohistochemistry staining was used to detect p33^ING1b expression in NSCLC and non-neoplasia lung tissues. Results The positive rate of p33^ING1b in NSCLC was significantly lower than those in non-tumorous lung tissues （ P 〈 0.05 ）. The down-regulation of the expression of p33^ING1b was related to differentiation and TNM stages, as well as to lymphnode metastasis. The positive rate of p33^ING1b in poorly differentiated group was significantly lower than those in well and moderately-differ-entiated group（ P 〈 0.05 ）. The positive rates of p33^ING1b in Ⅲ-ⅣWstages and lymph node metastases groups were significantly lower than those in Ⅰ-Ⅱ stages and the groups without lymph node metastasis （P 〈0.05）. Conclusion The expression of p33^ING1b is reduced in NSCLC. The down-expression of p33^ING1b is useful for evaluating the malignancy level ,invasion and metastasis of NSCLC.

关 键 词：肺癌 p33~ING1b 免疫组化 

分 类 号：R734.2[医药卫生—肿瘤]