VEGF-C在乳腺癌中的表达及临床意义  

Expression and clinical significance of VEGF-C in breast carcinoma

作　　者：高海燕[1] 吴丽华[2] 石岩[2] 张艳梅[2] 

机构地区：[1]哈尔滨医科大学第二临床医学院血液科,黑龙江哈尔滨150081 [2]哈尔滨医科大学第二临床医学院病理科,黑龙江哈尔滨150081

出　　处：《哈尔滨医科大学学报》2010年第4期358-361,共4页Journal of Harbin Medical University

摘　　要：目的分析研究血管内皮生长因子(vascularendothelial growth factor-C,VEGF-C)在乳腺癌中的表达与淋巴结转移的关系。方法 RT-PCR法检测乳腺癌中VEGF-C的表达情况。结果乳腺癌中VEGF-C的表达水平升高,90例乳腺癌中62例可检测到VEGF-CmRNA,阳性率为68.9%;乳腺癌组织中VEGF-C的阳性表达率淋巴结转移组高于无淋巴结转移组,两者差异具有显著性(P<0.05);临床分期Ⅲ、Ⅳ期的乳腺癌组织中VEGF-C阳性表达率明显高于Ⅰ、Ⅱ期,差异有显著性(P<0.01),在不同年龄、肿瘤直径、病理分型中,VEGF-C的阳性表达率相比较,差异无显著性(P>0.05)。结论 VEGF-C在转录和翻译水平的过度表达是乳腺癌的普遍现象。VEGF-C在乳腺癌中表达增高,与乳腺癌的淋巴结转移密切相关,对乳腺癌的淋巴结转移起重要作用,对VEGF-C/VEGFR-3信号调控通道干预有望成为治疗乳腺癌淋巴道转移的新靶点,对临床治疗有重要的指导意义。Objective To study the relationship of the expression of VEGF-C and lymph node metastasis in breast carcinoma. Methods RT-PCR were used to detect the expression of VEGF-C in breast carcinoma. Restdts The expression of VEGF-C increased in breast carcinoma, VEGF-CmRNA was found in 62 of 90 cases, the positive rate was 68.9% ; the positive expression rate of VEGF-C in breast carcinoma was higher in group with lymph node metastasis than that in group without lymph node metastasis, the difference was significant （ P 〈 0.05 ） ; the positive expression rate of VEGF-C in breast carcinoma of clinical stage Ⅲ and Ⅳ was higher than that of stage Ⅰ and Ⅱ, the difference was significant （P 〈 0. 01 ）. There was no correlation among the positive expression rate of VEGF-C and age of patients, tumor size and histological type of tumor, the difference was not significant （ P 〉 O. 05 ）. Conclusion VEGF-C overexpression in transcriptive and translational level is universal phenomenon in breast carcino- ma. The higher expression of VEGF-C in breast carcinoma is closely correlated with lymph node metasta- sis and plays important role in lymph node metastasis and has important significance in interventing VEGF-C/VEGFR-3 signal regulation passageway, which becomes a new target in treating lymph node metastasis of breast carcinoma .

关 键 词：乳腺肿瘤 VEGF—C 淋巴转移 RT—PCR 

分 类 号：R737.9[医药卫生—肿瘤]