光敏剂e4光动力学治疗小鼠S-180肉瘤的实验研究  

The effect of photodynamic therapy (PDT) with chlorine e4 on S-180 sarcoma in mice

作　　者：黎静[1] 李陆振[1] 张为民[1] 王晓怀[1] 李志强[1] 宣敏[1] 

机构地区：[1]广州军区广州总医院肿瘤科,广东广州510010

出　　处：《现代肿瘤医学》2010年第9期1695-1697,共3页Journal of Modern Oncology

基　　金：广东省自然科学基金资助项目(2006B36001001)

摘　　要：目的:利用激光激活e4,研究对在体小鼠S180肉瘤的杀伤作用,证明e4是可以选用的新型光敏剂之一。方法:荷瘤小鼠腹腔注射e4(40mg/kg)1次,6小时后用强度为24W/cm2的激光照射肿瘤区域1次,时间为20分钟(PDT组)。以空白对照组(C),光照组(Light)(激光强度为20W/cm2),光敏剂组(e4)为对照组,每两天测量肿瘤的大小,12天后剥离肉瘤并称重比较。结果:e4在小鼠体内经激光激活后可明显抑制肿瘤生长,PDT组肿瘤的平均重量较空白对照组肿瘤的平均重量要轻,两者比较有统计学意义,P=0.0000,光敏剂组肿瘤的平均重量较空白对照组肿瘤的平均重量要轻,两者比较有统计学意义,P=0.0068。结论:e4光动力治疗对小鼠S-180肉瘤有明显杀伤或抑制作用,e4自身对小鼠S-180肉瘤有一定杀伤或抑制作用。Objective：To investigate the effect of photodynamic therapy （PDT） with chlorine e4（e4） on S-180 sarcoma in mice.Methods：The mice with s-180 sarcoma were injected with e4（40mg/kg）.6 hours later,1.0MHz ultrasound was used to irradiated the tumor area for 180s.The intensity of light was 20W/cm^2.Then the volume of tumor was monitored every 2 days.The tumor bearing mice allocated to following groups ： sham-treatment （control,C）; light treatment （Light）; e4 treatment （e4 40mg/kg,ip） without light treatment,（e4）; e4 ＋ light treatment （PDT）.Results： The significant tumor growth inhibition was seen in group eP.Conclusion：PDT with e4 can inhibit growth of mouse S-180 sarcoma ,e4 can inhibit growth of mouse S-180 sarcoma.

关 键 词：CHLORINE e4 S-180肉瘤 小鼠 光动力治疗 

分 类 号：R730.3[医药卫生—肿瘤]