Lewis y抗原及整合素α_5、β_1在卵巢浆液性肿瘤中的表达及意义  

The expression and significance of Lewis y antigen and integrin α_5,β_1 in ovarian serous tumor

作　　者：刘水策[1] 李全荣[1] 林蓓[1] 严丽梅[1] 刘晴[1] 朱连成[1] 王逸飞[2] 王长智[2] 张淑兰[1] 

机构地区：[1]中国医科大学附属盛京医院妇产科,辽宁沈阳110004 [2]大连医科大学附属第二医院妇产科,辽宁大连116000

出　　处：《现代肿瘤医学》2010年第9期1804-1809,共6页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(项目编号:30170980;30571958;30872757);辽宁省自然基金资助项目(项目编号:20052107);教育部博士点基金资助项目(项目编号:20070159023);辽宁省教育厅重点实验室项目(2008S247);盛京自由研究者计划(200807)

摘　　要：目的:研究Lewis y抗原及整合素α5、β1在卵巢浆液性肿瘤中的表达及其意义。方法:应用免疫组织化学方法检测30例卵巢浆液性囊腺癌、11例交界性卵巢浆液性囊腺瘤、13例卵巢浆液性囊腺瘤、11例正常卵巢组织中Lewis y抗原及整合素α5、β1的表达情况。结果:Lewis y抗原在卵巢浆液性囊腺癌中的阳性表达率为90.0%,明显高于交界性(63.6%)、良性卵巢浆液性囊腺瘤(38.5%)及正常卵巢组织(0)中的表达(P均<0.05)。整合素α5、β1在卵巢浆液性囊腺癌中的阳性表达率分别为86.7%和83.3%,高于两者在交界性(72.7%,72.7%)、良性卵巢浆液性囊腺瘤(69.2%,53.8%)及正常卵巢组织(36.4%,36.4%)中的表达(P均<0.05)。Lewis y抗原及整合素α5、β1在卵巢浆液性囊腺癌中的表达呈显著正相关(P均<0.01)。结论:Lewis y抗原及整合素α5、β1在卵巢浆液性囊腺癌中的阳性表达率普遍增高,且两者的表达呈显著性正相关。提示Lewis y抗原及整合素α5、β1在卵巢浆液性囊腺癌的发生、发展中起着重要作用。Objective：To detect the expression of Lewis y and integrin α5,β1 in ovarian serous tumor and the significance. Methods： Thirty cases with ovarian serous cystadenocarcinoma, 11 cases with borderline serous cystadenoma, 13 cases with benign serous cystadenoma and 11 cases with ovary normal tissues were investigated. Immunohistochemestry was used to detect the expressions of Lewis y and integrin α5,β1. Results： The positive expression rate of Lewis y in ovary serous cystadenocarcinoma was 90.0%, obviously higher than borderline ovary tumors（63.6%）,benign ovary tumors（38.5%） and normal ovarian tissues（0） （P all 〈0.01）. Integrin α5,β1 expressed positively in 86.7% and 83.3% of ovarian serous cystadenocarcinoma, higher than that of borderline ovary tumors（72.7%, 72.7%）,benign ovary tumors（69.2%, 53.8%） and normal ovarian tissues（36.4%, 36.4%） （P all 〈0.05）. There was a positive correlation between the expression of Lewis y antigen and integrin α5,β1（P all〈0.01）. Conclusion： The expression of Lewis y and integrin α5,β1 increased in ovarian serous cystadenocarcinoma compared with the borderline,benign and normal cases, suggesting up-regulation of Lewis y and integrin α5,β1 may play an important role in the pathogenesis and development of ovary cancer.

关 键 词：LEWIS y抗原 整合素Α5 整合素Β1 卵巢浆液性肿瘤 免疫组织化学 

分 类 号：R737.31[医药卫生—肿瘤]