三维适形放疗及化疗对宫颈癌患者性激素的影响  

Effects of three-dimensional conformal radiotherapy and chemotherapy on sex hormones of the patients with cervical cancer

作　　者：陈宏伟[1] 刘孜[1] 汪涛[1] 李明众[1] 

机构地区：[1]西安交通大学医学院第一附属医院肿瘤放疗科,陕西西安710061

出　　处：《现代肿瘤医学》2010年第9期1817-1819,共3页Journal of Modern Oncology

摘　　要：目的:探讨宫颈癌患者三维适形放疗或同步放化疗对性激素的影响。方法:66例宫颈鳞状细胞癌的初发初治患者均行三维适形放疗(3DCRT)外照射和后装治疗。45例行1周期PF方案化疗,顺铂(DDP)40mgd1-3,5-氟尿嘧啶(5-FU)500mgd1-5。66例患者中8例绝经。在治疗前及治疗结束后分别用放射免疫法检测性激素。结果:所有66例患者经放疗或放疗加化疗后,FSH、LH升高到近3倍(P<0.05),E2下降近1半(P<0.05),P下降到近1/3(P<0.05)。45例患者经放疗加化疗治疗后,除了FSH、LH升高到3倍(P<0.05),E2下降近1半(P<0.05),P下降到近1/3外(P<0.05)外,T也下降(P<0.05)。21例未加化疗的患者治疗后,FSH升高到2.4倍(P<0.05),LH升高到近3倍(P<0.05),E2下降近1半(P<0.05)。8例绝经患者治疗后,FSH、LH、E2、P及T的变化不显著。结论:同步放化疗较单独放疗对宫颈癌患者卵巢分泌功能的影响大。Objective：To explore the effect of three-dimensional conformal radiotherapy or radiotherapy and concurrent chemotherapy on sex hormones of the patients with cervical cancer. Methods： Sixty six primary patients of cervical cancer were enrolled in the trial. All patients were treated by 3DCRT（three-dimensional conformal radiotherapy） external beam radiation and intracavitary brachytherapy after-loading therapy. Forty five patients were treated by chemotherapy, one period of cisplatin（CDDP） and 5-fluorouracil（5-FU） regimen, CDDP 40mg d1-3, 5-FU 500mg d1-5. Eight patients were menopause. Sex hormones were measured by radioimmunity before and after treatment . Results： FSH and LH of sixty six patients after treatment increased nearly three times than that of before treatment（P〈0.05）, E2 decrease nearly a half（P〈0.05）, P decrease nearly two-third（P〈0.05）. Except FSH and LH of forty five patients after radiotherapy and chemotherapy increase nearly three times than that of before treatment（P〈0.05）, E2 decrease nearly a half（P〈0.05）, P decreased nearly two-third（P〈0.05）, T decreased also（P〈0.05）. In twenty one patients without chemotherapy, FSH increased 2.4 times（P〈0.05）, LH increased nearly three times（P〈0.05） and E2 decreased nearly a half than that of before treatment（P〈0.05）. FSH, LH, E2, P and T had no significant changes in eight menopausal patients. Conclusion： Radiotherapy and concurrent chemotherapy have significant effects on sex hormones of the patients with cervical cancer than that of radiotherapy alone.

关 键 词：宫颈肿瘤 三维适形放射治疗 化疗 性激素 激素替代治疗 卵巢移位 

分 类 号：R737.3[医药卫生—肿瘤]