铝酞菁:人癌细胞的吸收及光敏杀伤的研究  

ALUMINUM PHTHALOCYANINE: A STUDY OF ITS LTTATE AND PHOTOCYTOTOXICITY IN HUMAN CANCER CELLS

作　　者：陈暨耀[1] 蔡怀新[1] 闵红波[2] 吕发度[2] 余宏宇[2] 董荣春[2] 

机构地区：[1]复旦大学物理系 [2]第二军医大学病理解剖教研室

出　　处：《生物物理学报》1990年第4期426-430,共5页Acta Biophysica Sinica

摘　　要：本文比较了光敏剂铝酞菁(AISPC)及血卟啉衍生物(HPD)在人癌细胞的吸收及光敏杀伤中的差异.探讨了两光敏剂在细胞中的分布、摄入量,血清的影响、及细胞对两光敏剂的吸收动力学过程,结果显示,除了类似的特征外,细胞对AISPC的吸收速度慢于HPD.光敏杀伤的结果表明,在红光照射下,两光敏剂对细胞有相近的杀伤效率;在室内自然光下,AISPC对细胞的损伤明显低于HPD,显示出其较低的光毒付作用,具有适合临床应用的优点.The different of cellular uptake and photocytotoxicity of sulfonated aluminum phtralocyanine I AISPC and haematoporphyrin cerinative HPD were investigated Some factors, such as photosensitizer's distribution in cells, the amount of cell -associated photosensitizer, the serum's effect and the kinetics of cellular uptake be studied The results showed that, besides the similar characteristics of two photosensitizers, the speed of AISPC uptake of cells is slower than that of HPD uptake. Experiments of photosensitization exhibited that, when irradiated with red light, the photodamaging effects on cells of both photosensitizers are close to each other; but when exposed to room light the cytotoxic effect of AISPC is lower than that of HPD, suggesting a potential advantage of reducing undesired side effects in clinical application.

关 键 词：癌细胞 铝酞菁 吸收 光敏杀伤 

分 类 号：R73－33[医药卫生—肿瘤]