羟乙基壳聚糖的合成及其与聚乳酸的相容性  

Synthesis of hydroxyethyl chitosan and its compatibility with poly(D,L-lactide)

作　　者：钟翠红[1] 罗丙红[1] 周长忍[1] 何柱国[1] 

机构地区：[1]暨南大学理工学院材料科学与工程系生物材料实验室人工器官与材料教育部工程中心,广州510632

出　　处：《化学研究与应用》2010年第9期1102-1107,共6页Chemical Research and Application

基　　金：国家自然科学基金资助项目(30500128);国家高技术研究发展计划(863计划)资助项目(2007AA091603);暨南大学"211工程"生物材料与组织工程"创新基金项目

摘　　要：本文以异丙醇为溶剂,碱化壳聚糖与2-氯乙醇反应制备了羟乙基壳聚糖,对产物的结构与性能进行了分析表征;然后以二甲基亚砜为溶剂,采用溶液共混法制备了一系列不同组成的壳聚糖/聚乳酸和羟乙基壳聚糖/聚乳酸复合膜,对两组分间的相容性进行了研究。结果表明,羟乙基化反应在-OH和-NH2上均有发生,壳聚糖单元糖环上的羟乙基取代度为2.46;改性后,壳聚糖结晶性能和起始热分解温度下降,溶解性能得到改善。复合膜的电镜结果显示,在壳聚糖/聚乳酸复合膜中,相分离现象显著存在,壳聚糖在聚乳酸基体中的分散不均匀,有团聚现象,随着壳聚糖含量增加,两组分间的相分离程度增大,团聚现象更为严重,当壳聚糖含量达到50%时,已难以制备完整的复合膜;与之相反,羟乙基壳聚糖/聚乳酸复合膜中两种组分之间的相容性有所改善,相分离现象不明显,并且,当羟乙基壳聚糖含量从10%增加到50%,复合膜中两种组分之间的相容性变化不大。In this paper,hydroxyethyl chitosan was synthesized by reacting 2-chloroethanol with alkalified chitosan in isopropanol.The product was characterized by FT IR,EA,1H NMR,XRD and DSC.Furthermore,a series of chitosan/poly（D,L-lactide）（CS/PDLLA） and hydroxyethyl chitosan/poly（D,L-lactide）（HECS/PDLLA） blend films were prepared by solution co-blending using dimethyl sulfoxide as a solvent.The compatibility of blend films was studied.The results of FT IR and 1H NMR showed that the hydroxyethylating reaction not only happened on hydroxyl groups,but also on amino group,and the degree of substitution of the hydroxyethyl group in aminoglucoside unit of the chitosan was 2.46 obtained by EA.The crystallinity and beginning decomposition temperature of chitosan decreased and its solubility was significantly improved after hydroxyethylation modification.SEM results indicated that phase separation was obviously existent in CS/PDLLA blend films,and the dispersion of chitosan in polylactide matrix was asymmetrical with agglomeration.With the content of chitosan increasing,phase separation and agglomeration were much more serious.When the content of chitosan was up to 50%,it was difficult to form a complete blend film.In contrast,the compatibility of HECS/PDLLA blend films has been perfected.With the contents of hydroxyethyl chitosan rose from 10% to 50%,the compatibility of HECS/PDLLA blend films has not changed too much.

关 键 词：壳聚糖 羟乙基壳聚糖 聚乳酸 复合膜 相容性 

分 类 号：O636.1[理学—高分子化学]