基于吡啶-水体系的2′-羟基查耳酮环化反应研究  

Study on the cyclization of 2′-hydroxychalcone based on pyridine-water system

作　　者：何文香[1] 郑旭煦[1] 殷钟意[1] 谢晶晶[1] 熊长海[1] 

机构地区：[1]重庆工商大学环境与生物工程学院药物化学与化学生物学研究中心,重庆400067

出　　处：《化学研究与应用》2010年第9期1142-1146,共5页Chemical Research and Application

基　　金：教育部科学技术研究重点项目(208119)资助;重庆工商大学研究生创新科研项目(yjscxx2009-07)资助项目

摘　　要：以2′-羟基查耳酮为原料,吡啶-水溶液为催化剂,分别在加热和光照条件下合成黄烷酮,考察了吡啶-水体积比、加热温度、光照强度、反应时间等因素的影响。结果表明,当吡啶-水体积比为4∶6,加热温度为90℃,反应时间为1 h时,黄烷酮产率达89.0%;在吡啶-水体积比为4∶6下,采用500W氙灯辐射7.5 h,黄烷酮产率达93.7%。An approach to the synthesis of flavanone in heating or lighting conditions was investigated respectively with 2＇-hydroxychalcone as raw material and pyridine-water solution as catalytic agent.The main influence factors including volume ratio of pyridine-water,reaction temperature or light intensity,reaction time were discussed.The results showed that when the volume ratio of pyridine-water was 4∶6,the heating temperature was 90℃,the reaction time was 1 h,the yield of flavanone was 89.0%;and when the volume ratio of pyridine-water was 4∶6,the light intensity was 500 W（xenon lamp）,the irradiation time was 7.5 h,the yield of flavanone was 93.7%.

关 键 词：2’-羟基查耳酮 黄烷酮 吡啶-水 加热 光照 

分 类 号：O625[理学—有机化学]