微创血肿清除术对脑出血患者血清S100水平的影响  

Effect of mini-invasive hematoma aspiration on content of S100 in patients with cerebral hemorrhage

作　　者：郑茂永 刘敬花[2] 张清华[3] 冯建利[3] 张桂茹[3] 

机构地区：[1]山东莱芜市矫形康复医院,莱芜250031 [2]山东省交通医院,济南250020 [3]山东大学附属省立医院神经内科,济南250020

出　　处：《中国实用神经疾病杂志》2010年第21期11-13,共3页Chinese Journal of Practical Nervous Diseases

基　　金：山东省自然科学基金项目(Y2008C27)

摘　　要：目的探讨微创血肿清除术对脑出血患者血清S100蛋白水平的影响。方法住院脑出血患者80例,随机分为微创手术组38例和保守治疗组42例。在入院当时及2、4、7、14 d各留取血液标本一次,测定血清中S100蛋白含量。在入院时和7、14、21 d进行欧洲卒中量表(ESS)和日常生活能力(ADL)评分。结果脑出血患者入院时血清S100含量即有升高,微创组与保守组S100水平均在第2天达到高峰,第4、7、14天时微创组S100水平低于保守组(P<0.05),微创组神经功能缺损、生活能力神经功能缺损和生活能力评分明显高于保守组(P<0.05)。结论微创穿刺血肿清除术能降低ICH患者血清S100蛋白水平,并利于神经功能早期恢复。Objective To observe the effect of mini-invasive hematoma aspiration on changes of serum S100 concentrations in patients with acute cerebral hemorrhage. Methods Eighty patients were divided into aspiration treatment group and conservative treatment group. Serum SI00 concentrations were measured at hospital admission and 2,4,7,14 days after symptom onset. The European stroke scale （ESS） and activities of daily living scale （ADL） were evaluated at hospital admission and 7,14,21 days after symptom onset. Results The serum level of S100 increased significantly at hospital admission. Peak serum level of S100 was found at 2nd day. S100 in aspiration treatment group was significantly lower than conservative treatment group at 4, 7,14 days（P〈0.05）. The EES, ADL were significantly higher in aspiration group than those in conservative group（P〈0.05）. Conclusion Mini-invasive hematoma aspiration for cerebral hemorrhage can decrease the serum S100 level. The aspiration can reduce brain damage in the treatment of intraeerebral hemorrhage.

关 键 词：脑出血 微创血肿清除术 S100 

分 类 号：R743.34[医药卫生—神经病学与精神病学]