低频振幅fMRI评价精神分裂症患者静息状态下脑功能活动  

Amplitude of low-frequency fluctuation study of resting-state functional MRI in schizophrenia

作　　者：刘虎[1] 范国光[1] 徐克[1] 李焕焕[1] 邵建[2] 

机构地区：[1]中国医科大学附属第一医院放射科,辽宁沈阳110001 [2]中国人民解放军沈阳军区总医院放射科,辽宁沈阳110016

出　　处：《中国医学影像技术》2010年第9期1659-1662,共4页Chinese Journal of Medical Imaging Technology

摘　　要：目的采用低频振幅(ALFF)方法评价精神分裂症患者静息状态下脑功能活动。方法对13例符合精神分裂症诊断标准的患者(精神分裂症组)及18名健康志愿者(正常对照组)行静息态脑fMR扫描,精神分裂症患者和正常对照者的ALFF差异用双样本t检验。结果与正常对照组相比,精神分裂症组静息状态下右侧胼胝体压部、右侧枕叶、左侧小脑后叶、左侧额上回和左侧楔前叶脑区ALFF增高,差异有统计学意义(P<0.001,未校正);双侧中央后回和左侧楔前叶脑区ALFF降低,差异有统计学意义(P<0.001,未校正)。结论精神分裂症患者静息状态下脑功能存在异常,ALFF有助于对精神分裂症患者静息状态脑功能的理解。Objective To evaluate brain activity in resting-state of schizophrenia patients with amplitude of low-frequency fluctuation （ALFF）. Methods Thirteen schizophrenia patients and 18 healthy controls underwent functional MR examination in resting-state, and the difference of ALFF between patients and controls was analyzed with two-sample t test. Results Compared with controls, significantly increasing areas of ALFF in resting-state of schizophrenia included right splenium of corpus callosum, right occipital lobe, left posterior lobe of cerebellum, left superior frontal gyrus and left precuneus （P0.001, uncorrected）, and the decreasing areas included bilateral postcentral gyrus and left precuneus （P0.001, uncorrected）. Conclusion The resting-state fMRI study suggests abnormal brain activity of schizophrenia might exist in resting state, and ALFF might contribute to the understanding of schizophrenia patients＇ brain function in resting state.

关 键 词：精神分裂症 磁共振成像 低频振幅 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]