鼻咽癌组织PAR1和VEGF及MMP1表达相关性的探讨  

Co-expressions of protease-activated receptor-1 VEGF and MMP1 in nasopharyngeal carcinoma tissues and their significance

作　　者：王涛[1] 皮国良[1] 伍钢[1] 陈叶珊[1] 刘伟[1] 梁丹丹[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院肿瘤中心,湖北武汉430023

出　　处：《中华肿瘤防治杂志》2010年第16期1277-1279,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:检测PAR1和VEGF及MMP1在鼻咽癌组织中的共表达及意义。方法:免疫组织化学(SP法)检测61例鼻咽癌组织中PAR1与VEGF、MMP1的表达,并比较PAR1与VEGF、MMP1的表达相关性。结果:PAR1、VEGF和MMP1的阳性表达率分别为78.7%(48/61)、59.0%(41/61)和77.0%(47/61)。PAR1与VEGF在鼻咽癌中的表达正相关(r=0.319,P=0.013),PAR1与MMP1在鼻咽癌中的表达无明显相关性(r=0.192,P=0.152)。结论:PAR1可能协同VEGF参与鼻咽癌的肿瘤血管生存。PAR1在鼻咽癌中的具体作用及详细机制有待进一步深入研究。OBJECTIVE：To investigate the co-expressions of PAR1,VEGF（vascular endothelial growth factor） and MMP1（matrix metalloprotease-1） in nasopharyngeal carcinoma （NPC） tissues and their significance.METHODS：The immunohistochemical method （SP method） was used to detect PAR1,VEGF and MMP1 expressions in 61 cases of NPC.The correlation between PAR1 expression and VEGF expression,and the correlation between PAR1 expression and MMP1 expression were inrestigated.RESULTS：PAR1、VEGF and MMP1 positive expression rates were 78.7%（48/61）,59.0%（41/61） and 77.0%（47/61） respectively.The positive correlation was found between PAR1 expression and VEGF expression （r=0.539,P=0.001）,while such correlation was not found between PAR1 expression and MMP1 expression （r=0.186,P=0.052）.CONCLUSIONS：PAR1 may contribute to some step of the tumor angiogenesis in NPC with the synergism of VEGF.The detailed significance and exactly mechanism of PAR1 in NPC should be researched further.

关 键 词：鼻咽肿瘤 蛋白酶活化受体-1 血管内皮生长因子 基质金属蛋白酶1 转移 

分 类 号：R739.63[医药卫生—肿瘤]