1992分期与2008分期对初治鼻咽癌患者远处转移的预测价值  

Value of predicting metastasis by 1992 staging system and 2008 staging system in nasopharyngeal carcinoma patients

作　　者：徐敏[1] 林焕新[1] 孙蕊[1] 廖家华[1] 黄培钰[1] 郭灵[1] 

机构地区：[1]华南肿瘤学国家重点实验室,中山大学肿瘤防治中心鼻咽癌科,广东广州510060

出　　处：《中华肿瘤防治杂志》2010年第16期1293-1297,共5页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:评价鼻咽癌1992分期和2008分期对远处转移的预测价值,为鼻咽癌分期系统的进一步修订和完善提供建议。方法:收集2004-01-01-2004-12-31中山大学肿瘤医院初治经病理学确诊无远处转移且有鼻咽和颈部MRI资料的鼻咽癌住院患者781例,比较两种分期系统各T、N及临床分期与转移的关系。结果:在T分期方面,2008分期对远处转移的预测价值优于1992分期;在N分期方面,2008和1992分期各有优势。2008分期N1a远处转移风险比(HR)及死亡风险比与N0较接近,将这部分患者归为T分期后,各N分期对远处转移的预测更合理。结论:2008分期系统在预测远处转移方面优于1992分期系统。颈部淋巴结阴性患者的咽后淋巴结归属问题值得进一步探讨。OBJECTIVE：To evaluate the value of predicting metastasis by 1992 staging system and 2008 staging system in nasopharyngeal carcinoma （NPC） patients.METHODS：From 01-01-2004 to 12-31-2004,781 patients with biopsy-proven newly diagnosed nonmetastatic nasopharyngeal cancer who had MRI data of nasopharynx and neck were enrolled.By using the two different NPC staging systems （1992 and 2008）,the relationship among T stage,N stage,clinical stage and distant metastasis was itvestigated.RESULTS：In terms of T stage,2008 NPC staging system was better than 1992 NPC staging system to forecast distant metastasis.For N stage,the different staging system had its own advantages.The hazard ratio（HR） of distant metastasis and death was similar in N1a and N0 of 2008 staging system.When these N1a patients were put into T stage,2008 staging system was more rational to forecast distant metastasis.CONCLUSIONS：2008 NPC staging system is better than 1992 NPC staging system to predict NPC distant metastasis.Retropharyngeal nodes should be further investigated for neck nodes negative patients.

关 键 词：鼻咽肿瘤/放射疗法 肿瘤分期 肿瘤转移 预后 

分 类 号：R739.63[医药卫生—肿瘤]